Early during Drosophila oogenesis the 16 interconnected cells of each germ-line cyst
choose between two alternative fates. The single future oocyte enters meiosis, arrests, and …

Over-replication of two clusters of chorion genes inDrosophila ovarian follicle cells is essential
for rapid eggshell biosynthesis. The relationship of this amplification to the follicle cell …

During metazoan development, the organization of the cell cycle is often modified in
response to developmental signals. The endocycle provides a dramatic example of this …

The synaptonemal complex (SC) is intimately involved in the process of meiotic recombination
in most organisms, but its exact role remains enigmatic. One reason for this uncertainty is …

Drosophila ovarian cysts arise through a series of four synchronous incomplete mitotic
divisions. After each round of mitosis, a membranous organelle, the fusome, grows along the …

Regulated changes in the cell cycle underlie many aspects of growth and differentiation.
Prior to meiosis, germ cell cycles in many organisms become accelerated, synchronized, and …

Animal oocytes undergo a highly conserved developmental arrest in prophase of meiosis I.
The maintenance of the prophase I arrest requires the silencing of Cdk1 activity. Drosophila …

Development of a fertilized egg into an adult human requires trillions of cell divisions, the
vast majority of which duplicate their genome once and only once. Nevertheless, trophoblast …

In multicellular lives, the differentiation of stem cells and progenitor cells is often
accompanied by a transition from glycolysis to mitochondrial oxidative phosphorylation (OXPHOS). …

The endocycle is a commonly observed variant cell cycle in which cells undergo repeated
rounds of DNA replication with no intervening mitosis. How the cell cycle machinery is …