Hyperactivation of the Caenorhabditis elegans MEC-4 Na + channel of the DEG/ENaC
superfamily (MEC-4(d)) induces neuronal necrosis through an increase in intracellular Ca 2+ and …

Limiting the debilitating consequences of ageing is a major medical challenge of our time.
Robust pharmacological interventions that promote healthy ageing across diverse genetic …

Regular physical exercise is the most efficient and accessible intervention known to promote
healthy aging in humans. The molecular and cellular mechanisms that mediate system-…

DEG/ENaC channel subunits are two transmembrane domain proteins that assemble into
heteromeric complexes to perform diverse biological functions that include sensory perception…

The sperm of Caenorhabditis elegans translocate in a fashion similar to sperm of Ascaris
suum even though their pseudopods are longer, more plastic in shape, and form multiple …

The Caenorhabditis Intervention Testing Program (CITP) seeks to identify compounds that
robustly improve lifespan and/or attenuate age-dependent declines in health across a …

She did not live to make those corrections which every such work requires, and the reader's
indulgence is claimed for faults of composition arising from these circumstances. In …

Background: In vitro and observational epidemiological studies suggest that vitamin D may
play a role in cancer prevention. However, the relationship between vitamin D and ovarian …

DEG/ENaC channel subunits are twotransmembrane domain proteins that assemble into
heteromeric complexes to perform diverse biological functions that include sensory perception, …

Exercise can protect against cardiovascular disease, neurodegenerative disease, diabetes,
cancer, and age-associated declines in muscle, immune, and cognitive function. In fact, …