User profiles for Mary E. Dickinson
Mary E DickinsonBaylor College of Medicine Verified email at bcm.edu Cited by 13777 |
High-throughput discovery of novel developmental phenotypes
Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting
from knockouts of these genes in mice have provided tremendous insight into gene function …
from knockouts of these genes in mice have provided tremendous insight into gene function …
Vascular remodeling of the mouse yolk sac requires hemodynamic force
The embryonic heart and vessels are dynamic and form and remodel while functional. Much
has been learned about the genetic mechanisms underlying the development of the …
has been learned about the genetic mechanisms underlying the development of the …
The embryonic vertebrate heart tube is a dynamic suction pump
…, HJ Tsai, JR Hove, SE Fraser, ME Dickinson… - Science, 2006 - science.org
The embryonic vertebrate heart begins pumping blood long before the development of
discernable chambers and valves. At these early stages, the heart tube has been described as a …
discernable chambers and valves. At these early stages, the heart tube has been described as a …
Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium
Although next-generation sequencing has revolutionized the ability to associate variants with
human diseases, diagnostic rates and development of new therapies are still limited by a …
human diseases, diagnostic rates and development of new therapies are still limited by a …
Multi-spectral imaging and linear unmixing add a whole new dimension to laser scanning fluorescence microscopy
ME Dickinson, G Bearman, S Tille, R Lansford… - …, 2001 - Future Science
Multicolor fluorescence microscopy has become a popular way to discriminate between
multiple proteins, organelles, or functions in a single cell or animal and can be used to …
multiple proteins, organelles, or functions in a single cell or animal and can be used to …
Biomimetic hydrogels with pro-angiogenic properties
…, JE Leslie-Barbick, SH Lee, AA Smith, ME Dickinson… - Biomaterials, 2010 - Elsevier
To achieve the task of fabricating functional tissues, scaffold materials that can be sufficiently
vascularized to mimic functionality and complexity of native tissues are yet to be developed. …
vascularized to mimic functionality and complexity of native tissues are yet to be developed. …
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation
J Wang, NS Hamblet, S Mark, ME Dickinson… - 2006 - journals.biologists.com
The planar cell polarity (PCP) pathway is conserved throughout evolution,but it mediates
distinct developmental processes. In Drosophila,members of the PCP pathway localize in a …
distinct developmental processes. In Drosophila,members of the PCP pathway localize in a …
[HTML][HTML] The NIH somatic cell genome editing program
The move from reading to writing the human genome offers new opportunities to improve
human health. The United States National Institutes of Health (NIH) Somatic Cell Genome …
human health. The United States National Institutes of Health (NIH) Somatic Cell Genome …
[HTML][HTML] Prevalence of sexual dimorphism in mammalian phenotypic traits
…, SDM Brown, EJ Chesler, ME Dickinson… - Nature …, 2017 - nature.com
The role of sex in biomedical studies has often been overlooked, despite evidence of sexually
dimorphic effects in some biological studies. Here, we used high-throughput phenotype …
dimorphic effects in some biological studies. Here, we used high-throughput phenotype …
In situ hybridization analysis of TGFβ3 RNA expression during mouse development: comparative studies with TGFβ1 and β2
RW Pelton, ME Dickinson, HL Moses… - …, 1990 - journals.biologists.com
To date, three closely-related TGFβ genes have been found in the mouse; TGFβ1, TGFβ2
and TGFβ3. Previous experiments have indicated that TGFβ1 and TGFβ2 may play important …
and TGFβ3. Previous experiments have indicated that TGFβ1 and TGFβ2 may play important …