Use of high‐resolution micro–computed tomography (µCT) imaging to assess trabecular and
cortical bone morphology has grown immensely. There are several commercially available …

Background Parathyroid hormone increases bone strength primarily by stimulating bone
formation, whereas antiresorptive drugs reduce bone resorption. We conducted a randomized, …

Context: Assessment of trabecular microarchitecture may enhance the prediction of fracture
risk and improve monitoring of treatment response. A new high-resolution peripheral …

Osteoporosis and obesity, two disorders of body composition, are growing in prevalence.
Interestingly, these diseases share several features including a genetic predisposition and a …

Bone densitometry using dual‐photon absorptiometry (DPA) or dual‐energy x‐ray absorptiometry
(DXA) has become a standard method for assessing bone mineral content in the spine …

In a population‐based, cross‐sectional study, we assessed age‐ and sex‐specific changes
in bone structure by QCT. Over life, the cross‐sectional area of the vertebrae and proximal …

Skeletal development and turnover occur in close spatial and temporal association with
angiogenesis. Osteoblasts are ideally situated in bone to sense oxygen tension and respond to …

To examine the local actions of IGF signaling in skeletal tissue in a physiological context,
we have used Cre-mediated recombination to disrupt selectively in mouse osteoblasts the …

Mutations in the Wnt co-receptor LRP5 alter bone mass in humans, but the mechanisms
responsible for Wnts actions in bone are unclear. To investigate the role of the classical Wnt …

Background: Higher fat mass may be an independent risk factor for osteoporosis and
osteoporotic fractures. Objective: We aimed to determine the independent contribution of fat mass …