Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic
glioma driving alterations and suboptimal disease classification. We defined the complete …

Object Laser interstitial thermal therapy has been used as an ablative treatment for glioma;
however, its development was limited due to technical issues. The NeuroBlate System …

This study was undertaken to compare the efficacy and safety of tacrolimus (Tac) with the
microemulsion formulation of cyclosporin (CyA) in children undergoing renal transplantation. A …

Sexual dimorphism at the level of MDSC subset prevalence, localization, and gene-expression
profile constitutes a therapeutic opportunity. Our results indicate that chemotherapy can …

Glioblastoma (GBM) remains uniformly lethal, and despite a large accumulation of immune
cells in the microenvironment, there is limited antitumor immune response. To overcome …

BACKGROUND Myeloid-derived suppressor cells (MDSCs) are elevated in the circulation
of patients with glioblastoma (GBM), present in tumor tissue, and associated with poor …

Immunotherapies in patients with GBM have been unsuccessful due to a variety of factors,
including the highly immunosuppressive tumor microenvironment in GBM. This study …

This study was undertaken to compare the efficacy and safety of tacrolimus (Tac) with cyclosporin
microemulsion (CyA) in pediatric renal recipients. A 6‐month, randomized, prospective…

Objective To report the evidence for and challenges to the validity of Sheffield Peer Review
Assessment Tool (SPRAT) with paediatric Specialist Registrars (SpRs) across the UK as part …

Twelve children who have had chronic renal failure since infancy and underwent early
dialysis (mean age 18 months) and early transplantation (mean age 28 months) were studied. …