Objective To develop updated guidelines for the pharmacologic management of rheumatoid
arthritis. Methods We developed clinically relevant population, intervention, comparator, …

Background: Patients with chronic inflammatory disease (CID) treated with immunosuppressive
medications have increased risk for severe COVID-19. Although mRNA-based SARS-…

Osteoclasts, the only bone-resorbing cells, are central to the pathogenesis of osteoporosis,
yet their development and regulation are incompletely understood. Multiple receptors of the …

DAP12 is an ITAM-containing adapter that associates with receptors in myeloid and NK cells.
DAP12-associated receptors can give activation signals leading to cytokine production; …

Ferritin is a spherical molecule composed of 24 subunits of two types, ferritin H chain (FHC)
and ferritin L chain (FLC). Ferritin stores iron within cells, but it also circulates and binds …

Following neuronal injury, microglia initiate repair by phagocytosing dead neurons without
eliciting inflammation. Prior evidence indicates triggering receptor expressed by myeloid cells…

The immunoreceptor tyrosine‐based activation motif (ITAM) is a highly conserved region in
the cytoplasmic domain of signaling chains and receptors and is a critical mediator of …

Clearing cellular debris after brain injury represents an important mechanism in regaining
tissue homeostasis and promoting functional recovery. Triggering receptor expressed on …

Objective Glucocorticoid (GC) excess induces alterations in bone metabolism that weaken
bone structure and increase fracture risk. The aim of this study was to identify genes …

Dendritic cells (DCs), which are known to support immune activation during infection, may
also regulate immune homeostasis in resting animals. Here we show that mice lacking the …