User profiles for Marzia Munafò
 | Marzia MunafòPost-doctoral Fellow, EMBL Verified email at embl.it Cited by 731 |
piRNA-guided genome defense: from biogenesis to silencing
PIWI-interacting RNAs (piRNAs) and their associated PIWI clade Argonaute proteins constitute
the core of the piRNA pathway. In gonadal cells, this conserved pathway is crucial for …
the core of the piRNA pathway. In gonadal cells, this conserved pathway is crucial for …
[PDF][PDF] Dis3l2-mediated decay is a quality control pathway for noncoding RNAs
Mutations in the 3′-5′ exonuclease DIS3L2 are associated with Perlman syndrome and
hypersusceptibility to Wilms tumorigenesis. Previously, we found that Dis3l2 specifically …
hypersusceptibility to Wilms tumorigenesis. Previously, we found that Dis3l2 specifically …
piRNA-guided co-transcriptional silencing coopts nuclear export factors
10.7554/eLife.47999.001 The PIWI-interacting RNA (piRNA) pathway is a small RNA-based
immune system that controls the expression of transposons and maintains genome integrity …
immune system that controls the expression of transposons and maintains genome integrity …
Specialization of the Drosophila nuclear export family protein Nxf3 for piRNA precursor export
The PIWI-interacting RNA (piRNA) pathway is a conserved small RNA-based immune system
that protects animal germ cell genomes from the harmful effects of transposon mobilization…
that protects animal germ cell genomes from the harmful effects of transposon mobilization…
Daedalus and Gasz recruit Armitage to mitochondria, bringing piRNA precursors to the biogenesis machinery
M Munafò, V Manelli, FA Falconio, A Sawle… - Genes & …, 2019 - genesdev.cshlp.org
The Piwi-interacting RNA (piRNA) pathway is a small RNA-based immune system that silences
mobile genetic elements in animal germlines. piRNA biogenesis requires a specialized …
mobile genetic elements in animal germlines. piRNA biogenesis requires a specialized …
Exonuclease requirements for mammalian ribosomal RNA biogenesis and surveillance
Ribosomal RNA (rRNA) biogenesis is a multistep process requiring several nuclear and
cytoplasmic exonucleases. The exact processing steps for mammalian 5.8S rRNA remain …
cytoplasmic exonucleases. The exact processing steps for mammalian 5.8S rRNA remain …
Systematic epigenome editing captures the context-dependent instructive function of chromatin modifications
C Policarpi, M Munafò, S Tsagkris, V Carlini, JA Hackett - BioRxiv, 2022 - biorxiv.org
Chromatin modifications are linked with regulating patterns of gene expression, but their
causal role and context-dependent impact on transcription remains unresolved. Here, we …
causal role and context-dependent impact on transcription remains unresolved. Here, we …
Dimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in Drosophila
EL Eastwood, KA Jara, S Bornelöv, M Munafo… - Elife, 2021 - elifesciences.org
In animal gonads, the PIWI-interacting RNA (piRNA) pathway guards genome integrity in
part through the co-transcriptional gene silencing of transposon insertions. In Drosophila …
part through the co-transcriptional gene silencing of transposon insertions. In Drosophila …
Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function
Microsatellite expansions of CCTG repeats in the cellular nucleic acid-binding protein (CNBP)
gene leads to accumulation of toxic RNA and have been associated with myotonic …
gene leads to accumulation of toxic RNA and have been associated with myotonic …
Channel nuclear pore complex subunits are required for transposon silencing in Drosophila
M Munafò, VR Lawless, A Passera, S MacMillan… - Elife, 2021 - elifesciences.org
The nuclear pore complex (NPC) is the principal gateway between nucleus and cytoplasm
that enables exchange of macromolecular cargo. Composed of multiple copies of ~30 …
that enables exchange of macromolecular cargo. Composed of multiple copies of ~30 …