Background The underlying mechanism of dynamic control of the genome-wide expression
is a fundamental issue in bioscience. We addressed it in terms of phase transition by a …

Background A fundamental issue in bioscience is to understand the mechanism that underlies
the dynamic control of genome-wide expression through the complex temporal-spatial self…

Toll-like receptors (TLRs) are the archetypal pattern recognition receptors in sensing exogenous
pathogens. Activation of TLRs is a first line of defense of the immune system, leading to …

The human DNA molecule is a 2–m-long polymer collapsed into the micrometer space of the
cell nucleus. This simple consideration rules out any “Maxwell demon”-like explanation of …

Herein, we provide a brief overview of complex systems theory approaches to investigate the
genomic mechanism of cell-fate changes. Cell trajectories across the epigenetic landscape…

Large-scale gene expression studies have mainly focused on highly expressed and ‘discriminatory’
genes to decipher key regulatory processes. Biological responses are consequence …

We examine the coordinated behavior of thousands of genes in cell fate transitions through
genome expression as an integrated dynamical system using the concepts of self-organized …

Elucidation of the genomic mechanism that guides the cell-fate change is one of the
fundamental issues of biology. We previously demonstrated that whole genome expression is …

Understanding the basic mechanism of the spatio-temporal self-control of genome-wide
gene expression engaged with the complex epigenetic molecular assembly is one of major …

An exacerbated sensitivity to apparently minor stimuli and a general resilience of the entire
system stay together side-by-side in biological systems. This apparent paradox can be …