Glucose uptake is essential for cancer glycolysis and is involved in non-shivering thermogenesis
of adipose tissues 1 , 2 , 3 , 4 , 5 – 6 . Most cancers use glycolysis to harness energy for …

Induced pluripotent stem cells (iPSCs) are a type of pluripotent stem cells generated directly
from mature cells through the introduction of key transcription factors. iPSCs can be …

The human ovary orchestrates sex hormone production and undergoes monthly structural
changes to release mature oocytes. The outer lining of the ovary (cortex) has a key role in …

Enhancers are distal cis-regulatory DNA elements that increase the expression of target
genes. Various experimental and computational approaches including chromatin signature …

Embryonic genome activation (EGA) is critical for embryonic development. However, our
understanding of the regulatory mechanisms of human EGA is still incomplete. Human …

Induced pluripotent stem cell (iPSC) reprogramming is inefficient and understanding the
molecular mechanisms underlying this inefficiency holds the key to successfully control cellular …

Double homeobox 4 (DUX4) is expressed at the early pre-implantation stage in human embryos.
Here we show that induced human DUX4 expression substantially alters the chromatin …

Generation of human-induced pluripotent stem cells (iPSCs) from somatic cells has opened
the possibility to design novel therapeutic approaches. In 2014, the first-in-human clinical …

Background Fetal immune tolerance is crucial for pregnancy success. We studied the link
between preeclampsia, a severe pregnancy disorder with uncertain pathogenesis, and fetal …

Induced pluripotent stem cells (iPSCs) are generated by direct reprogramming of somatic
cells and hold great promise for novel therapies. However, several studies have reported …