Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans
W Yamashiro, K Maeda, M Hirouchi, Y Adachi… - Drug metabolism and …, 2006 - ASPET
Valsartan is a highly selective angiotensin II AT1-receptor antagonist for the treatment of
hypertension. Valsartan is mainly excreted into the bile in unchanged form. Because valsartan …
hypertension. Valsartan is mainly excreted into the bile in unchanged form. Because valsartan …
[HTML][HTML] CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model
…, A Bond, BM Rivera, MC Sullivan, M Hirouchi… - Nature …, 2023 - nature.com
Microglia are central to pathogenesis in many neurological conditions. Drugs targeting
colony-stimulating factor-1 receptor (CSF1R) to block microglial proliferation in preclinical …
colony-stimulating factor-1 receptor (CSF1R) to block microglial proliferation in preclinical …
Characterization of the cellular localization, expression level, and function of SNP variants of MRP2/ABCC2
M Hirouchi, H Suzuki, M Itoda, S Ozawa… - Pharmaceutical …, 2004 - Springer
Purpose. The presence of single nucleotide polymorphisms (SNPs) has been reported for
multidrug resistance-associated protein 2 (MRP2/ABCC2). The purpose of the current study …
multidrug resistance-associated protein 2 (MRP2/ABCC2). The purpose of the current study …
Human pharmacokinetic prediction of UDP-glucuronosyltransferase substrates with an animal scale-up approach
…, K Fusegawa, N Suzuki, S Murata, M Hirouchi… - Drug metabolism and …, 2011 - ASPET
The aim of the current study was to evaluate the accuracy of allometric scaling methods for
drugs metabolized by UDP-glucuronosyltransferases (UGTs), such as ketoprofen, imipramine…
drugs metabolized by UDP-glucuronosyltransferases (UGTs), such as ketoprofen, imipramine…
Discovery of DS-1558: a potent and orally bioavailable GPR40 agonist
…, T Ogata, N Watanabe, M Hirouchi… - ACS medicinal …, 2015 - ACS Publications
GPR40 is a G protein-coupled receptor that is predominantly expressed in pancreatic β-cells.
GPR40 agonists stimulate insulin secretion in the presence of high glucose concentration. …
GPR40 agonists stimulate insulin secretion in the presence of high glucose concentration. …
Increasing systemic exposure of methotrexate by active efflux mediated by multidrug resistance-associated protein 3 (mrp3/abcc3)
Y Kitamura, M Hirouchi, H Kusuhara, JD Schuetz… - … of Pharmacology and …, 2008 - ASPET
The aim of this study was to investigate the functional importance of multidrug resistance-associated
protein (Mrp)3/Abcc3 and Mrp4/Abcc4 in the pharmacokinetics of methotrexate. …
protein (Mrp)3/Abcc3 and Mrp4/Abcc4 in the pharmacokinetics of methotrexate. …
Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATP1B1 …
M Hirouchi, H Kusuhara, R Onuki, BW Ogilvie… - Drug metabolism and …, 2009 - ASPET
Multidrug resistance-associated protein (MRP) 3/ABCC3 and MRP4/ABCC4 are ATP-binding
cassette (ABC) transporters expressed in the sinusoidal membrane of hepatocytes. The …
cassette (ABC) transporters expressed in the sinusoidal membrane of hepatocytes. The …
[HTML][HTML] Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4
…, K Kubo, T Yabuki, A Hattori, M Hirouchi… - Journal of Biological …, 2012 - ASBMB
Multidrug resistance-associated protein 4 (MRP4/ABCC4) makes a vital contribution to the
bodily distribution of drugs and endogenous compounds because of its cellular efflux abilities. …
bodily distribution of drugs and endogenous compounds because of its cellular efflux abilities. …
Evaluation of the usefulness of breast cancer resistance protein (BCRP) knockout mice and BCRP inhibitor-treated monkeys to estimate the clinical impact of BCRP …
…, T Imaoka, T Mikkaichi, S Yasuda, M Hirouchi… - Pharmaceutical …, 2015 - Springer
Purpose To evaluate whether the impact of functional modulation of the breast cancer resistance
protein (BCRP, ABCG2 421C>A) on human pharmacokinetics after oral administration …
protein (BCRP, ABCG2 421C>A) on human pharmacokinetics after oral administration …
Integrated approach of in vivo and in vitro evaluation of the involvement of hepatic uptake organic anion transporters in the drug disposition in rats using rifampicin as …
T Imaoka, T Mikkaichi, K Abe, M Hirouchi… - Drug Metabolism and …, 2013 - ASPET
Cumulative studies describe the importance of drug transporters as one of the key determinants
of pharmacokinetics that necessitate investigation and assessment of the involvement of …
of pharmacokinetics that necessitate investigation and assessment of the involvement of …