Integration of sensory and molecular inputs from the environment shapes animal behaviour.
A major site of exposure to environmental molecules is the gastrointestinal tract, in which …

Using untargeted metabolomics (n = 1,162 subjects), the plasma metabolite (m/z = 265.1188)
phenylacetylglutamine (PAGln) was discovered and then shown in an independent cohort (…

The gut microbiota synthesize hundreds of molecules, many of which influence host physiology.
Among the most abundant metabolites are the secondary bile acids deoxycholic acid (…

The gut microbiota modulate host biology in numerous ways, but little is known about the
molecular mediators of these interactions. Previously, we found a widely distributed family of …

Recent studies show gut microbiota-dependent metabolism of dietary phenylalanine into
phenylacetic acid (PAA) is critical in phenylacetylglutamine (PAGln) production, a metabolite …

Type III polyketide synthases (PKSs) found in plants, fungi, and bacteria synthesize a variety
of aromatic polyketides. A Gram-positive, filamentous bacterium Streptomyces griseus …

Purpose: EGFR-tyrosine kinase inhibitor (TKI) is a standard first-line therapy for activated
EGFR-mutated non–small cell lung cancer (NSCLC). Treatment options for patients with …

Dihydroxyphenylalanine (DOPA) melanins formed from tyrosine by tyrosinases are found in
microorganisms, plants, and animals. Most species in the soil-dwelling, gram-positive …

Phenotype-based drug discovery is a key strategy for small molecule drug screening, and
the molecular target identification of small molecules, termed “target deconvolution,” is critical …

A-503083 B, a capuramycin-type antibiotic, contains an L-aminocaprolactam and an
unsaturated hexuronic acid that are linked via an amide bond. A putative class C β-lactamase (…