[PDF][PDF] Loss of Sfpq causes long-gene transcriptopathy in the brain

A Takeuchi, K Iida, T Tsubota, M Hosokawa, M Denawa… - Cell reports, 2018 - cell.com
Genes specifically expressed in neurons contain members with extended long introns.
Longer genes present a problem with respect to fulfilment of gene length transcription, and …

[HTML][HTML] Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia

M Ajiro, T Awaya, YJ Kim, K Iida, M Denawa… - Nature …, 2021 - nature.com
Approximately half of genetic disease-associated mutations cause aberrant splicing. However,
a widely applicable therapeutic strategy to splicing diseases is yet to be developed. Here, …

Identification of a dual inhibitor of SRPK1 and CK2 that attenuates pathological angiogenesis of macular degeneration in mice

…, T Okabe, H Kojima, N Inoue, Y Okuno, M Denawa… - Molecular …, 2015 - ASPET
Excessive angiogenesis contributes to numerous diseases, including cancer and blinding
retinopathy. Antibodies against vascular endothelial growth factor (VEGF) have been …

[HTML][HTML] Evidence for lateral gene transfer (LGT) in the evolution of eubacteria-derived small GTPases in plant organelles

IN Suwastika, M Denawa, S Yomogihara… - Frontiers in plant …, 2014 - frontiersin.org
The genomes of free-living bacteria frequently exchange genes via lateral gene transfer (LGT),
which has played a major role in bacterial evolution. LGT also played a significant role in …

P‐Type ATPase Superfamily: Evidence for Critical Roles for Kingdom Evolution

H Okamura, M Denawa, R Ohniwa… - Annals of the New …, 2003 - Wiley Online Library
The P‐type ATPase has become a protein superfamily. On the basis of sequence similarities,
the phylogenetic analyses, and substrate specificities, this superfamily can be classified …

[PDF][PDF] S1PR3–G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation

M Toyomoto, A Inoue, K Iida, M Denawa, I Kii… - Cell Chemical …, 2021 - cell.com
Metabolic activities are altered in cancer cells compared with those in normal cells, and the
cancer-specific pathway becomes a potential therapeutic target. Higher cellular glucose …

Perspective factor: a novel indicator for the assessment of journal quality

RL Ohniwa, M Denawa, M Kudo… - Research …, 2004 - academic.oup.com
‘Impact factor (IF)’ has been practically the only indicator to assess journal quality. However,
it has various problems associated with citation analysis, such as the effects of ‘different …

Identification of the α2 chain of interleukin‐13 receptor as a potential biomarker for predicting castration resistance of prostate cancer using patient‐derived xenograft …

…, S Akamatsu, T Kobayashi, K Iida, M Denawa… - Cancer …, 2023 - Wiley Online Library
Background Several treatment strategies use upfront chemotherapy or androgen receptor
axis‐targeting therapies for metastatic prostate cancer. However, there are no useful …

Retinoid derivative Tp80 exhibits anti‐hepatitis C virus activity through restoration of GI‐GPx expression

…, Y Okuno, M Ajiro, K Iida, M Denawa… - Journal of Medical …, 2017 - Wiley Online Library
Hepatitis C virus (HCV) is a positive‐sense single‐stranded RNA virus with an estimated
infection in ∼180 million people worldwide, and its chronic infection leads to development of …

Synthetic ligand promotes gene expression by affecting GC sequence in promoter

S Matsumoto, K Iida, A Murata, M Denawa… - Bioorganic & medicinal …, 2017 - Elsevier
A naphthyridine carbamate tetramer (NCT8) is a synthetic compound, which selectively binds
to nucleic acids containing CGG/CGG sequence. Although NCT8 is a promising compound …