Health professionals are encouraged to take the Guidelines fully into account when
exercising their clinical judgment, as well as in the determination and the implementation of …

Mandibuloacral dysplasia (MAD) is a rare autosomal recessive disorder, characterized by
postnatal growth retardation, craniofacial anomalies, skeletal malformations, and mottled …

Background— Aging is a major risk factor for the development of atherosclerosis and
coronary artery disease. Through a microarray approach, we have identified a microRNA (miR-217…

Hepatic steatosis is a multifactorial condition that is often observed in obese patients and is
a prelude to non-alcoholic fatty liver disease. Here, we combine shotgun sequencing of fecal …

Insulin receptor substrate (IRS) molecules are key mediators in insulin signaling and play a
central role in maintaining basic cellular functions such as growth, survival, and metabolism. …

• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient’s interest …

Type 2 diabetes is characterized by insulin resistance and inadequate insulin secretion. In
the advanced stages of the disease, β-cell dysfunction worsens and insulin therapy may be …

Background— Hyperglycemia impairs functional properties of cytosolic and nuclear proteins
via O-linked glycosylation modification (O-GlcNAcylation). We studied the effects of O-…

Obesity-related disease complications reduce life quality and expectancy and increase
health-care costs. Some studies have suggested that obesity not always entails metabolic …

Background: The formation of the NLRP3 inflammasome in the heart during acute myocardial
infarction amplifies the inflammatory response and mediates further damage. Glyburide …