Current concepts suggest that exposure to THC during adolescence may act as a risk factor
for the development of psychiatric disorders later in life. However, the molecular …

Deficits in executive functions are key features of schizophrenia. Rodent behavioral paradigms
used so far to find animal correlates of such deficits require extensive effort and time. The …

10.7554/eLife.30697.001 A sudden aversive event produces escape behaviors, an innate
response essential for survival in virtually all-animal species. Nuclei including the lateral …

Developing new tools that outperform current state of the art technologies for imaging, drug
delivery or electrical sensing in neuronal tissues is one of the great challenges in …

Endocannabinoids (eCBs) regulate neuronal activity in the dorso-lateral striatum (DLS), a
brain region that is involved in habitual behaviors. How synaptic eCB signaling contributes to …

The lateral habenula encodes aversive stimuli contributing to negative emotional states
during drug withdrawal. Here we report that morphine withdrawal in mice leads to microglia …

Throughout life, individuals learn to predict a punishment via its association with sensory
stimuli. This process ultimately prompts goal-directed actions to prevent the danger, a behavior …

Copy-number variants of the CYFIP1 gene in humans have been linked to autism spectrum
disorders (ASD) and schizophrenia (SCZ), two neuropsychiatric disorders characterized by …

Weighing alternatives during reward pursuit is a vital cognitive computation that, when
disrupted by stress, yields aspects of neuropsychiatric disorders. To examine the neural …

Monoaminergic modulation of cortical and thalamic inputs to the dorsal striatum (DS) is
crucial for reward-based learning and action control. While dopamine has been extensively …