Background: Previous investigations suggest that maltreated children with a diagnosis of
posttraumatic stress disorder (PTSD) evidence alterations of biological stress systems. …

Although dementia praecox or schizophrenia has been considered a unique disease entity
for the past century, its definitions and boundaries have continued to vary over this period. At …

Background: This investigation examined the relationship between trauma, psychiatric
symptoms and urinary free cortisol (UFC) and catecholamine (epinephrine [EPI], norepinephrine […

Although we have studied schizophrenia as a major disease entity over the past century, its
causes and pathogenesis remain obscure. In this article, we critically review genetic and …

Brain development during childhood and adolescence is characterized by both progressive
myelination and regressive pruning processes. However, sex differences in brain maturation …

BACKGROUND: Previous investigations suggest that maltreated children evidence alterations
of chemical mediators of stress and adverse brain development. Previous anatomical …

Cognitive and brain maturational changes continue throughout late childhood and adolescence.
During this time, increasing cognitive control over behavior enhances the voluntary …

OBJECTIVE: Alcohol use disorders (defined as DSM-IV alcohol dependence or abuse) are
prevalent and serious problems among adolescents. As adolescence is marked by …

Several lines of evidence support the notion that a substantial reorganization of cortical
connections, involving a programmed synaptic pruning, takes place during adolescence in …

Objective: Clinical phenomenology remains the primary means for classifying psychoses
despite considerable evidence that this method incompletely captures biologically meaningful …