Cellular senescence, a process that imposes permanent proliferative arrest on cells in response
to various stressors, has emerged as a potentially important contributor to aging and age…

The senescence programme is implicated in diverse biological processes, including
embryogenesis, tissue regeneration and repair, tumorigenesis, and ageing. Although in vivo studies …

Cellular senescence, a stress-induced irreversible growth arrest often characterized by
expression of p16 Ink4a (encoded by the Ink4a/Arf locus, also known as Cdkn2a) and a …

Modulation of the RAS (renin–angiotensin system), in particular of the function of the
hormones AngII (angiotensin II) and Ang-(1–7) [angiotensin-(1–7)], is an important target for …

Background Vascular dysfunction in atherosclerosis and diabetes mellitus, as observed in
the aging population of developed societies, is associated with vascular DNA damage and …

Despite the fact that the cell cycle is a fundamental process of life, a detailed quantitative
understanding of gene regulation dynamics throughout the cell cycle is far from complete. …

Young mammals possess a limited regenerative capacity in some tissues, which is lost upon
maturation. We investigated whether cellular senescence might play a role in such loss …

Reduced nitric oxide (NO)/cGMP signalling is observed in age-related vascular disease. We
hypothesize that this disturbed signalling involves effects of genomic instability, a primary …

Modulation of renin-angiotensin system (RAS) by angiotensin-(1–7) (Ang-(1–7)) is an
attractive approach to combat the detrimental consequences of myocardial infarction (MI). …

Angiotensin II type 2 (AT 2 ) receptor stimulation has been linked to vasodilation. Yet, AT 2
receptor-independent hypertension and hypotension (or no effect on blood pressure) have …