Paroxysmal depolarization shifts (PDS) have been described by epileptologists for the first
time several decades ago, but controversy still exists to date regarding their role in epilepsy. …

Several shortcomings with currently available pharmacotherapy of epilepsy necessitate the
search for new drug targets. Paroxysmal depolarization shifts (PDS) represent the cellular …

Diseases arising from misfolding of SLC6 transporters have been reported over recent years,
eg. folding-deficient mutants of the dopamine transporter and of the glycine transporter-2 …

L-type voltage-gated Ca 2+ channels (LTCCs) are implicated in neurodegenerative processes
and cell death. Accordingly, LTCC antagonists have been proposed to be neuroprotective…

Electrical activity in neurons is highly energy demanding and accompanied by rises in
cytosolic Ca 2+ . Cytosolic Ca 2+ , in turn, secures energy supply by pushing mitochondrial …

Objective An increase of neuronal Ca v 1.3 L‐type calcium channels ( LTCC s) has been
observed in various animal models of epilepsy. However, LTCC inhibitors failed in clinical trials …

10.7554/eLife.34944.001 Electrophysiological recordings allow for monitoring the operation
of proteins with high temporal resolution down to the single molecule level. This technique …

Intracellular calcium signals are studied by laser-scanning confocal fluorescence microscopy.
The required spatio-temporal resolution makes description of calcium signals difficult …

Acute intermittent porphyria (AIP) is an autosomal dominant inborn error of heme biosynthesis
due to a pathogenic mutation in the Hmbs gene, resulting in half-normal activity of …

Correct detection of membrane currents under whole-cell patch–clamp conditions is limited
by the transfer function of a recording system. The low-pass output filter of a recording …