Lung surfactant protein A (SP-A) plays an important function in modulating inflammation in
the lung. However, the exact role of SP-A and the mechanism by which SP-A affects IFN-γ–…

Macrophages can either promote or resolve inflammatory responses, and their polarization
state is modulated by peripheral serotonin (5-hydroxytryptamine [5-HT]). In fact, pro-and anti-…

Macrophages display a ample plethora of effector functions whose acquisition is promoted
by the surrounding cytokine and cellular environment. Depending on the stimulus, …

Peripheral serotonin (5-hydroxytryptamine, 5-HT) regulates cell growth and differentiation in
numerous cell types through engagement of seven types of cell surface receptors (HTR1–7)…

Besides its role as a neurotransmitter, serotonin (5-hydroxytryptamine, 5HT) regulates
inflammation and tissue repair via a set of receptors (5HT 1–7) whose pattern of expression varies …

IVIg is an approved therapy for immunodeficiency and for several autoimmune and inflammatory
diseases. However, the molecular basis for the IVIg anti-inflammatory activity remains to …

Upon inflammation, monocyte-derived macrophages (MΦ) infiltrate blood vessels to regulate
several processes involved in vascular pathophysiology. However, little is known about the …

Endoglin is an auxiliary receptor for members of the TGF-β superfamily and plays an important
role in the homeostasis of the vessel wall. Mutations in endoglin gene (ENG) or in the …

Intravenous Igs (IVIg) therapy is widely used as an immunomodulatory strategy in inflammatory
pathologies and is suggested to promote cancer regression. Because progression of …

Endoglin plays a crucial role in pathophysiological processes such as hereditary hemorrhagic
telangiectasia (HHT), preeclampsia and cancer. Endoglin expression is upregulated …