User profiles for Mateusz W. Kucharczyk

Mateusz W. Kucharczyk

IoPPN, King's College London
Verified email at kcl.ac.uk
Cited by 613

Distinct brainstem to spinal cord noradrenergic pathways inversely regulate spinal neuronal activity

MW Kucharczyk, F Di Domenico, K Bannister - Brain, 2022 - academic.oup.com
Brainstem to spinal cord noradrenergic pathways include a locus coeruleus origin projection
and diffuse noxious inhibitory controls. While both pathways are traditionally viewed as …

A critical brainstem relay for mediation of diffuse noxious inhibitory controls

MW Kucharczyk, F Di Domenico, K Bannister - Brain, 2023 - academic.oup.com
The CNS houses naturally occurring pathways that project from the brain to modulate spinal
neuronal activity. The noradrenergic locus coeruleus (the A6 nucleus) originates such a …

Activation of the descending pain modulatory system using cuff pressure algometry: Back translation from man to rat

TM Cummins, MM Kucharczyk… - … Journal of Pain, 2020 - Wiley Online Library
Background Diffuse noxious inhibitory controls (DNIC) as measured in rat and conditioned
pain modulation (CPM), the supposed psychophysical paradigm of DNIC measured in …

Introducing descending control of nociception: a measure of diffuse noxious inhibitory controls in conscious animals

K Bannister, MW Kucharczyk, T Graven-Nielsen… - Pain, 2021 - journals.lww.com
Ever since Le Bars et al. 21 detailed in 1979 that “the activity of convergent dorsal horn neurons
could be powerfully inhibited by noxious stimuli applied to various parts of the body,” 21 …

Developments in understanding diffuse noxious inhibitory controls: pharmacological evidence from pre-clinical research

MW Kucharczyk, D Valiente, K Bannister - Journal of pain research, 2021 - Taylor & Francis
Bulbospinal pathways regulate nociceptive processing, and inhibitory modulation of nociception
can be achieved via the activity of diffuse noxious inhibitory controls (DNIC), a unique …

[HTML][HTML] The impact of bone cancer on the peripheral encoding of mechanical pressure stimuli

MW Kucharczyk, KI Chisholm, F Denk, AH Dickenson… - Pain, 2020 - journals.lww.com
Skeletal metastases are frequently accompanied by chronic pain that is mechanoceptive in
nature. Mechanistically, cancer-induced bone pain (CIBP) is mediated by peripheral sensory …

[HTML][HTML] The stage-specific plasticity of descending modulatory controls in a rodent model of cancer-induced bone pain

MW Kucharczyk, D Derrien, AH Dickenson, K Bannister - Cancers, 2020 - mdpi.com
Simple Summary The mechanisms that underlie pain resulting from metastatic bone disease
remain elusive. This translates to a clinical and socioeconomic burden—targeted therapy is …

The origin of diffuse noxious inhibitory controls

MW Kucharczyk, F Di Domenico, K Bannister - bioRxiv, 2022 - biorxiv.org
Pain alerts us to actual or potential tissue damage. During acute pain, our central nervous
system acts endogenously to modulate pain processing, thus reducing or enhancing pain …

[HTML][HTML] Deep sequencing of Phox2a nuclei reveals five classes of anterolateral system neurons

AM Bell, C Utting, AC Dickie, MW Kucharczyk, R Quillet… - bioRxiv, 2023 - ncbi.nlm.nih.gov
The anterolateral system (ALS) is a major ascending pathway from the spinal cord that projects
to multiple brain areas and underlies the perception of pain, itch and skin temperature. …

Novel mechanisms of bone cancer pain revealed with in vivo GCaMP6s imaging

MW Kucharczyk, KI Chisholm, DM Lopes, D Derrien… - bioRxiv, 2018 - biorxiv.org
Skeletal metastases are frequently accompanied by chronic pain that is mechanoceptive in
nature and not easily managed by available therapies. The peripheral sensory profile of …