User profiles for Mathepan Mahendralingam

Mathepan Jeya Mahendralingam

MD/PhD Candidate, University of Toronto, Hospital for Sick Children
Verified email at mail.utoronto.ca
Cited by 192

Mammary stem cells and progenitors: targeting the roots of breast cancer for prevention

P Tharmapalan, M Mahendralingam, HK Berman… - The EMBO …, 2019 - embopress.org
Breast cancer prevention is daunting, yet not an unsurmountable goal. Mammary stem and
progenitors have been proposed as the cells‐of‐origin in breast cancer. Here, we present the …

Mammary epithelial cells have lineage-rooted metabolic identities

MJ Mahendralingam, H Kim, CW McCloskey… - Nature …, 2021 - nature.com
Cancer metabolism adapts the metabolic network of its tissue of origin. However, breast cancer
is not a disease of a single origin. Multiple epithelial populations serve as the culprit cell …

Press-fit fixation in anterior cruciate ligament reconstruction yields low graft failure and revision rates: a systematic review and meta-analysis

A Shanmugaraj, M Mahendralingam, C Gohal… - Knee Surgery, Sports …, 2021 - Springer
Purpose Press-fit fixation is a hardware-free technique in anterior cruciate ligament
reconstruction (ACLR). The purpose of this review was to quantitatively assess the risk profile and …

[PDF][PDF] Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages

…, BT Grünwald, L Palomero, MJ Mahendralingam… - Cell reports, 2023 - cell.com
It is widely assumed that all normal somatic cells can equally perform homologous recombination
(HR) and non-homologous end joining in the DNA damage response (DDR). Here, we …

A novel 3-dimensional co-culture method reveals a partial mesenchymal to epithelial transition in breast cancer cells induced by adipocytes

NK Pallegar, CJ Garland, M Mahendralingam… - Journal of mammary …, 2019 - Springer
Cancer metastases are accountable for almost 90% of all human cancer related deaths
including from breast cancer (BC). Adipocytes can alter the tumor microenvironment, which can …

[HTML][HTML] Identifying the murine mammary cell target of metformin exposure

…, PD Waterhouse, M Mahendralingam… - Communications …, 2019 - nature.com
The heterogeneity of breast cancer makes current therapies challenging. Metformin, the anti-diabetic
drug, has shown promising anti-cancer activities in epidemiological studies and …

Mammary epithelial cells have lineage-restricted metabolic identities

M Mahendralingam, K Aliar, A Elisabeth Casey… - biorxiv, 2019 - biorxiv.org
Cancer metabolism adapts the metabolic network of its tissue-of-origin. However, breast
cancer is not a disease of a singular origin. Multiple epithelial populations serve as the culprit …

Mammary lineage dictates homologous recombination repair and PARP inhibitor vulnerability

…, AE Casey, L Palomero, K Aliar, M Mahendralingam… - bioRxiv, 2021 - biorxiv.org
It has long been assumed that all normal cells have the same capacity to engage homologous
recombination (HR) and non-homologous end joining (NHEJ) to repair DNA double-…

[BOOK][B] Lineage-restricted metabolic identities of mammary epithelial cells

M Mahendralingam - 2019 - search.proquest.com
Cancer metabolism has been proposed to adapt the metabolic network from its tissue-of-origin.
However, breast cancer is not a disease of a singular origin. There are multiple epithelial …

Abstract A18: A novel 3D co-culture system for the study of adipocyte and extracellular matrix influences on the breast cancer phenotype

NK Pallegar, M Mahendralingam, A Viloria-Petit… - Cancer Research, 2017 - AACR
Breast cancer (BC) is the most common cancer among women worldwide. Among the different
subtypes of breast cancer, triple negative breast cancer (TNBC) is the most aggressive …