Westudied the roleof desensitization at inhibitory synapses by comparing nonequilibrium
GABAI channel gating with inhibitory postsynaptic currents (IPSCs). Currents activated by brief …

The role of desensitization of ligand-gated channels at fast chemical synapses has been
difficult to establish. Desensitization has been studied traditionally with prolonged agonist …

Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." …

Investigation of axonal biology in the central nervous system (CNS) is hindered by a lack of
an appropriate in vitro method to probe axons independently from cell bodies. Here we …

The germinal center (GC) is a microanatomical compartment wherein high-affinity antibody-producing
B cells are selectively expanded. B cells proliferate and mutate their antibody …

Neural stem cell (NSC) transplantation represents an unexplored approach for treating
neurodegenerative disorders associated with cognitive decline such as Alzheimer disease (AD). …

Microglia play critical roles in brain development, homeostasis, and neurological disorders.
Here, we report that human microglial-like cells (iMGLs) can be differentiated from iPSCs to …

Mutations in the GABA A receptor γ2 subunit are associated with childhood absence epilepsy
and febrile seizures. To understand better the molecular basis of absence epilepsy in man, …

1. The effects of the volatile anaesthetics enflurane, halothane and isoflurane on gamma‐aminobutyric
acid (GABA)A receptor‐mediated chloride currents were studied in cultured rat …

Neurofibrillary tangles (NFTs) are composed of abnormal aggregates of the cytoskeletal
protein tau. Together with amyloid β (Aβ) plaques and neuronal and synaptic loss, NFTs …