Imprinted genes display parent-of-origin-specific expression with this epigenetic system of
regulation found exclusively in therian mammals. Historically, defined imprinted gene …

Imprinted genes are regulated according to parental origin and can influence embryonic
growth and metabolism and confer disease susceptibility. Here, we designed sensitive allele-…

Transmission of epigenetic information between generations occurs in nematodes, flies and
plants, mediated by specialised small RNA pathways, modified histones and DNA …

Duchenne muscular dystrophy (DMD) is an X-linked disorder caused by loss of function
mutations in the dystrophin gene (Dmd), resulting in progressive muscle weakening. Here we …

BACKGROUND There is an increased incidence of rare imprinting disorders associated
with assisted reproduction technologies (ARTs). The identification of epigenetic changes at …

Cyclin-dependent kinases (CDKs) and their inhibitors (CDKIs) play pivotal roles in the
regulation of the cell cycle. As a result of these functions, it may be extrapolated that they are …

Mutations in the imprinted CDKN1C gene are associated with the childhood developmental
disorder Beckwith-Wiedemann syndrome (BWS). Multiple mouse models with deficiency of …

Pleckstrin homology-like domain family A member 2 (PHLDA2) is a maternally expressed
imprinted gene whose elevated expression has been linked to fetal growth restriction in a …

The remarkable process of light emission by living organisms has fascinated mankind for
thousands of years. A recent expansion in the repertoire of catalytic luciferase enzymes, …

Objective Imprinted genes are crucial for the growth and development of fetal and juvenile
mammals. Altered imprinted gene dosage causes a variety of human disorders, with growth …