INTRODUCTION Resolving the molecular details of proteome variation in the different tissues
and organs of the human body would greatly increase our knowledge of human biology …

DNA sequencing is one of the most important technologies in bioscience today. Whole-genome
approaches (1) and human expressed sequence tag (EST) sequencing (2) have started …

INTRODUCTION Cancer is a leading cause of death worldwide, and there is great need to
define the molecular mechanisms driving the development and progression of individual …

NATURE BIoTECHNoloGy volume 28 number 12 DeCember 2010 1249 the resulting
annotated protein expression. The annotated protein expression in the various cell types are …

Global classification of the human proteins with regards to spatial expression patterns across
organs and tissues is important for studies of human biology and disease. Here, we used a …

Advances in molecular profiling have opened up the possibility to map the expression of
genes in cells, tissues, and organs in the human body. Here, we combined single-cell …

INTRODUCTION A complete view of human biology can only be achieved by studying the
molecular components of its smallest functional unit, the cell. Cells are internally organized …

An approach for real-time DNA sequencing without the need for electrophoresis has been
developed. The approach relies on the detection of DNA polymerase activity by an enzymatic …

The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare
and society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐…

Antibody-based proteomics provides a powerful approach for the functional study of the
human proteome involving the systematic generation of protein-specific affinity reagents. We …