Antipsychotic polypharmacy in schizophrenia is much debated, since it is common and
costly with unclear evidence for its efficacy and safety. We conducted a systematic literature …

In general, rigorous data on combination therapy in schizophrenia are rare and further
randomized controlled trials, naturalistic trials and head-to-head-trials are necessary. Some …

Obsessive-compulsive disorder (OCD) is rarely associated with schizophrenia, whereas 20
to 30% of schizophrenic patients, suffer from comorbid obsessive-compulsive symptoms (…

Altered glucocorticoid receptor (GR) signaling is a postulated mechanism for the pathogenesis
of major depression. To mimic the human situation of altered GR function claimed for …

Common risk factors for psychiatric and other brain disorders are likely to converge on biological
pathways influencing the development and maintenance of brain structure and function …

Cytokine-dependent mechanisms in the CNS have been implicated in the pathogenesis of
depression. Interleukin-6 is upregulated in depressed patients and dowregulated by …

Importance Between-individual variability in brain structure is determined by gene-environment
interactions, possibly reflecting differential sensitivity to environmental and genetic …

Schizophrenia is increasingly recognized as a disorder of distributed neural dynamics, but
the molecular and genetic contributions are poorly understood. Recent work highlights a role …

… Mathias Zink has received unrestricted scientific grants of Servier and the German Research
Foundation (DFG); speaker and travel grants were provided from Astra Zeneca, Lilly, Pfizer …

A large subgroup of around 25% of schizophrenia patients suffers from obsessive-compulsive
symptoms (OCS) and about 12% fulfill the diagnostic criteria of an obsessive-compulsive …