SNARE (Soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins are
the core machinery of membrane fusion. Vesicular SNAREs (v-SNAREs) interact with their …

Rabs are the largest family of small GTPases and are master regulators of membrane trafficking.
Following activation by guanine‐nucleotide exchange factors (GEFs), each Rab binds a …

Cells inversely adjust the plasma membrane levels of integrins and cadherins during cell
migration and cell–cell adhesion but the regulatory mechanisms that coordinate these …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that selectively affects
motor neurons (MNs) of the cortex, brainstem, and spinal cord. Several genes have been …

Twenty years after the publication of the first draft of the human genome, our knowledge of
the human proteome is still fragmented. The challenge of translating the wealth of new …

The small guanosine triphosphatase Rab13 functions in exocytic vesicle trafficking in
epithelial cells. Alterations in Rab13 activity have been observed in human cancers, yet the …

The v-SNARE TI-VAMP (VAMP7) mediates exocytosis during neuritogenesis, phagocytosis
and lysosomal secretion. It localizes to endosomes and lysosomes but also to the trans-Golgi …

Amphiphysin 1, an endocytic adaptor concentrated at synapses that couples clathrin-mediated
endocytosis to dynamin-dependent fission, was also shown to have a regulatory role in …

Astrocytes play a number of key functions in health and disease. Activated astrocytes are
present in most, if not all, neurological diseases. Most current information on the mechanisms …

Mutations in leucine‐rich repeat kinase 2 ( LRRK 2) are the most common cause of
dominant‐inherited Parkinson's disease ( PD ), and yet we do not fully understand the physiological …