Epigenetic variations are more substantial than genetic variations in rapid adaptation of oyster to Pacific oyster mortality syndrome

…, M Laporte, J de Lorgeril, Y Gueguen, M Saccas… - Science …, 2023 - science.org
Disease emergence is accelerating with global changes. Understanding by which mechanisms
host populations can rapidly adapt will be crucial for management practices. Pacific …

[PDF][PDF] STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses

IK Vila, H Chamma, A Steer, M Saccas, C Taffoni… - Cell Metabolism, 2022 - cell.com
Concerted alteration of immune and metabolic homeostasis underlies several inflammation-related
pathologies, ranging from metabolic syndrome to infectious diseases. Here, we …

DNA damage repair kinase DNA‐PK and cGAS synergize to induce cancer‐related inflammation in glioblastoma

…, J Marines, H Chamma, S Guha, M Saccas… - The EMBO …, 2023 - embopress.org
Cytosolic DNA promotes inflammatory responses upon detection by the cyclic GMP‐AMP (cGAMP)
synthase (cGAS). It has been suggested that cGAS downregulation is an immune …

[HTML][HTML] TL-532, a novel specific Toll-like receptor 3 agonist rationally designed for targeting cancers: discovery process and biological characterization

…, L Dimier, C Perret, N Vey, S Ourfali, M Saccas… - Microbial Cell, 2023 - ncbi.nlm.nih.gov
Toll-like receptor 3 (TLR3) is an innate immune receptor that recognizes double-stranded
RNA (dsRNA) and induces inflammation in immune and normal cells to initiate anti-microbial …

Epigenetic then genetic variations underpin rapid adaptation of oyster populations (Crassostrea gigas) to Pacific Oyster Mortality Syndrome (POMS)

…, M Laporte, J de Lorgeril, Y Gueguen, M Saccas… - BioRxiv, 2023 - biorxiv.org
Disease emergence is accelerating in response to human activity-induced global changes.
Understanding the mechanisms by which host populations can rapidly adapt to this threat …

The crosstalk between DNA-PK and cGAS drives tumor immunogenicity

C Taffoni, J Marines, H Chamma, M Saccas, A Bouzid… - bioRxiv, 2022 - biorxiv.org
Cytosolic DNAs promote inflammatory responses upon detection by the cyclic GMP-AMP (cGAMP)
synthase (cGAS). It has been thus suggested that cGAS downregulation is an …

Reconstructing the dynamics of past coral endosymbiotic algae communities using coral ancient DNA (coraDNA)

O Rey, D Dissard, E Toulza, T Guinebert, M Saccas… - bioRxiv, 2024 - biorxiv.org
Most scleractinian corals are drastically threatened due to global changes but some colonies
are intriguingly resistant to heat stress. Coral thermal tolerance partly relies on genomic …

[PDF][PDF] Control of polyunsaturated fatty acids desaturation by Sting regulates inflammatory responses

…, A Steer, C Taffoni, LS Reinert, E Turtoi, M Saccas… - bioRxiv, 2020 - researchgate.net
Inflammatory disorders are major health issues in which immune function and metabolic
homeostasis are concertedly altered. Yet, how innate and metabolic pathways are coordinated, …

[PDF][PDF] STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses

S FADS - hal.science
Concerted alteration of immune and metabolic homeostasis underlies several inflammation-related
pathologies, ranging from metabolic syndrome to infectious diseases. Here, we …

[CITATION][C] Determinants and relative weight of genetic and epigenetic variation in the resistance of the oyster Crassostrea gigas to the Pacific Oyster Mortality …

…, J Gawra, J de Lorgeril, Y Gueguen, F Roux, M Saccas… - EPIMAR 2022, 2022 - hal.science
Determinants and relative weight of genetic and epigenetic variation in the resistance of the
oyster Crassostrea gigas to the Pacific Oyster Mortality Syndrome - Archive ouverte HAL …