Background Development of resistance to targeted therapies has tempered initial optimism
that precision oncology would improve poor outcomes for cancer patients. Resistance …

Motivation Intracellular signalling is realized by complex signalling networks, which are almost
impossible to understand without network models, especially if feedbacks are involved. …

Genomic features are used as biomarkers of sensitivity to kinase inhibitors used widely to
treat human cancer, but effective patient stratification based on these principles remains …

Signaling pathways implicated in cancer create a complex network with numerous
regulatory loops and redundant pathways. This complexity explains frequent failure of one-drug-one-…

HRAS, NRAS, and KRAS isoforms are almost identical proteins that are ubiquitously expressed
and activate a common set of effectors. In vivo studies have revealed that they are not …

For a short period during early development of mammalian embryos, both X chromosomes
in females are active, before dosage compensation is ensured through X‐chromosome …

Human diseases such as cancer are routinely characterized by high-throughput molecular
technologies, and multi-level omics data are accumulated in public databases at increasing …

Very high risk neuroblastoma is characterised by increased MAPK signalling, and targeting
MAPK signalling is a promising therapeutic strategy. We used a deeply characterised panel …

Cancer therapy has seen immense progress over the last century but resistance to drug
treatments remains a major obstacle in the war against cancer. I developed an R package …

Motivation: Intracellular signalling is realized by complex signalling networks, which are
almost impossible to understand without network models, especially if feedbacks are involved. …