Age is a common risk factor in many diseases, but the molecular basis for this relationship is
elusive. In this study we identified four disease clusters from 116 diseases in UK Biobank …

Although death is inevitable, individuals have long sought to alter the course of the ageing
process. Indeed, ageing has proved to be modifiable; by intervening in biological systems, …

At first glance, longevity and immunity appear to be different traits that have not much in
common except the fact that the immune system promotes survival upon pathogenic infection. …

Advancing age is the dominant risk factor for most of the major killer diseases in developed
countries. Hence, ameliorating the effects of ageing may prevent multiple diseases …

Aging is a major risk factor to develop neurodegenerative diseases and is associated with
decreased buffering capacity of the proteostasis network. We investigated the significance of …

Inhibition of signalling through several receptor tyrosine kinases (RTKs), including the insulin‐like
growth factor receptor and its orthologues, extends healthy lifespan in organisms from …

Alteration in the buffering capacity of the proteostasis network is an emerging feature of
Alzheimer's disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress. The …

Increasing human life expectancy has posed increasing challenges for healthcare systems.
As people age, they become more susceptible to chronic diseases, with an increasing …

Xanthophyllomyces dendrorhous is a natural source of astaxanthin, a carotenoid widely
used in the food industry. In this yeast, astaxanthin is synthesized from β-carotene by a …

Aging is the largest risk factor for a variety of noncommunicable diseases. Model organism
studies have shown that genetic and chemical perturbations can extend both lifespan and …