jMorp updates in 2020: large enhancement of multi-omics data resources on the general Japanese population

…, J Takayama, Y Okamura, Y Aoki, M Shirota… - Nucleic acids …, 2021 - academic.oup.com
In the Tohoku Medical Megabank project, genome and omics analyses of participants in two
cohort studies were performed. A part of the data is available at the Japanese Multi Omics …

Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project

…, I Motoike, D Saigusa, J Inoue, M Shirota… - Genes to …, 2018 - Wiley Online Library
Population‐based prospective cohort studies are indispensable for modern medical research
as they provide important knowledge on the influences of many kinds of genetic and …

[HTML][HTML] 3.5 KJPNv2: an allele frequency panel of 3552 Japanese individuals including the X chromosome

…, IN Motoike, Y Yamaguchi-Kabata, M Shirota… - Human Genome …, 2019 - nature.com
The first step towards realizing personalized healthcare is to catalog the genetic variations
in a population. Since the dissemination of individual-level genomic information is strictly …

jMorp: Japanese multi omics reference panel

…, IN Motoike, J Inoue, Y Aoki, M Shirota… - Nucleic acids …, 2018 - academic.oup.com
We developed jMorp, a new database containing metabolome and proteome data for plasma
obtained from >5000 healthy Japanese volunteers from the Tohoku Medical Megabank …

Variants that affect function of calcium channel TRPV6 are associated with early-onset chronic pancreatitis

…, Y Kakuta, T Niihori, R Funayama, M Shirota… - Gastroenterology, 2020 - Elsevier
Background & Aims Changes in pancreatic calcium levels affect secretion and might be
involved in development of chronic pancreatitis (CP). We investigated the association of CP with …

Genomic analysis identifies masqueraders of full‐term cerebral palsy

…, A Onuma, R Funayama, M Shirota… - Annals of Clinical …, 2018 - Wiley Online Library
Objective Cerebral palsy is a common, heterogeneous neurodevelopmental disorder that
causes movement and postural disabilities. Recent studies have suggested genetic diseases …

ATTED-II in 2014: evaluation of gene coexpression in agriculturally important plants

…, S Ito, S Tadaka, Y Aoki, M Shirota… - Plant and Cell …, 2014 - academic.oup.com
ATTED-II ( http://atted.jp ) is a database of coexpressed genes that was originally developed
to identify functionally related genes in Arabidopsis and rice. Herein, we describe an …

[HTML][HTML] Interethnic analyses of blood pressure loci in populations of East Asian and European descent

…, H Rakugi, E Nakashima, M Isono, M Shirota… - Nature …, 2018 - nature.com
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200
genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide …

[PDF][PDF] Lack of transcription triggers H3K27me3 accumulation in the gene body

M Hosogane, R Funayama, M Shirota, K Nakayama - Cell reports, 2016 - cell.com
Trimethylated H3K27 (H3K27me3) is associated with transcriptional repression, and its
abundance in chromatin is frequently altered in cancer. However, it has remained unclear how …

Cancer‐associated fibroblasts secrete Wnt2 to promote cancer progression in colorectal cancer

…, H Karasawa, R Funayama, M Shirota… - Cancer …, 2019 - Wiley Online Library
Recent studies have shown that the tumor microenvironment plays a significant role in the
progression of solid tumors. As an abundant component of the tumor microenvironment, …