Carbapenem resistance in Acinetobacter baumannii is a growing public health concern and
is most often mediated by OXA carbapenemases. We describe a novel multiplex …

Background Isolates of methicillin-resistant Staphylococcus aureus (MRSA) belonging to a
single lineage are often indistinguishable by means of current typing techniques. Whole-…

Sir, Carbapenems are considered a last-line agent for the treatment of serious Gram-negative
sepsis. Metallo-b-lactamases (MBLs) hydrolyse carbapenems efficiently and, when present…

Sir, CTX-M extended-spectrum b-lactamases (ESBLs) are increasingly prevalent worldwide
among Escherichia coli and Klebsiella spp., including in the UK, where over half of all …

Background The emergence of meticillin-resistant Staphylococcus aureus (MRSA) that can
persist in the community and replace existing hospital-adapted lineages of MRSA means that …

Whole genome sequencing (WGS) promises to be transformative for the practice of clinical
microbiology, and the rapidly falling cost and turnaround time mean that this will become a …

The discovery of antibiotics more than 80 years ago has led to considerable improvements
in human and animal health. Although antibiotic resistance in environmental bacteria is …

Objectives The aim of this study was to investigate relatedness and molecular mechanism(s)
of ertapenem resistance in clinical isolates of Klebsiella spp. (n = 28) and Enterobacter spp. …

The emergence of mutations in nucleic acids is one of the major factors underlying evolution,
providing the working material for natural selection. Most bacteria are haploid for the vast …

The emergence of the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) has
required an unprecedented response to control the spread of the infection and protect the …