User profiles for Matthew A. Kubit

Matthew Kubit

Verified email at allogene.com
Cited by 354

Single-cell RNA-Seq of follicular lymphoma reveals malignant B-cell types and coexpression of T-cell immune checkpoints

…, GXY Zheng, MA Kubit… - Blood, The Journal …, 2019 - ashpublications.org
Follicular lymphoma (FL) is a low-grade B-cell malignancy that transforms into a highly
aggressive and lethal disease at a rate of 2% per year. Perfect isolation of the malignant B-cell …

Joint single cell DNA-seq and RNA-seq of gastric cancer cell lines reveals rules of in vitro evolution

…, BT Lau, C Catalanotti, A Sathe, M Kubit… - NAR Genomics and …, 2020 - academic.oup.com
Cancer cell lines are not homogeneous nor are they static in their genetic state and biological
properties. Genetic, transcriptional and phenotypic diversity within cell lines contributes to …

Improved read/write cost tradeoff in DNA-based data storage using LDPC codes

…, K Tatwawadi, B Lau, J Mardia, M Kubit… - 2019 57th Annual …, 2019 - ieeexplore.ieee.org
With the amount of data being stored increasing rapidly, there is significant interest in exploring
alternative storage technologies. In this context, DNA-based storage systems can offer …

Overcoming high nanopore basecaller error rates for DNA storage via basecaller-decoder integration and convolutional codes

…, K Tatwawadi, J Mardia, B Lau, M Kubit… - ICASSP 2020-2020 …, 2020 - ieeexplore.ieee.org
As magnetization and semiconductor based storage technologies approach their limits, bio-molecules,
such as DNA, have been identified as promising media for future storage systems…

Improved detection and identification of microsatellite instability features in colorectal cancer: Implications for immunotherapy

G Shin, HJ Lee, SM Grimes, MA Kubit, HP Ji - Cancer Research, 2018 - AACR
Colorectal cancers with loss of DNA mismatch repair display microsatellite instability (MSI).
These tumors have a better prognosis and an improved response rate to immune check point …

Characterization of the consensus mucosal microbiome of colorectal cancer

L Zhao, SM Grimes, SU Greer, M Kubit, HJ Lee… - NAR …, 2021 - academic.oup.com
Dysbioisis is an imbalance of an organ's microbiome and plays a role in colorectal cancer
pathogenesis. Characterizing the bacteria in the microenvironment of a cancer through …

Joint single cell DNA-Seq and RNA-Seq of cancer reveals subclonal signatures of genomic instability and gene expression

…, K Sullivan-Bibee, A Weinstein, W Yang, Y Yin, M Kubit… - Biorxiv, 2018 - biorxiv.org
Sequencing the genomes of individual cancer cells provides the highest resolution of
intratumoral heterogeneity. To enable high throughput single cell DNA-Seq across thousands of …

[HTML][HTML] Whole genome analysis identifies the association of TP53 genomic deletions with lower survival in Stage III colorectal cancer

LC Xia, P Van Hummelen, M Kubit, HJ Lee, JM Bell… - Scientific reports, 2020 - nature.com
DNA copy number aberrations (CNA) are frequently observed in colorectal cancers (CRC).
There is an urgent need for CNA-based biomarkers in clinics,. n For Stage III CRC, if …

Tandem oligonucleotide probe annealing and elongation to discriminate viral sequence

M Taskova, J Uhd, L Miotke, M Kubit, J Bell… - Analytical …, 2017 - ACS Publications
New approaches for genomic DNA/RNA detection are in high demand in order to provide
controls for existing enzymatic technologies and to create alternatives for emerging …

The Gastric Cancer Registry: A Genomic Translational Resource for Multidisciplinary Research in Gastric Cancer

…, M McNamara, AC Hooker, MM Arce, M Kubit… - … Biomarkers & Prevention, 2022 - AACR
Background: Gastric cancer is a leading cause of cancer morbidity and mortality. Developing
information systems which integrate clinical and genomic data may accelerate discoveries …