User profiles for Matthew A. Kubit
Matthew KubitVerified email at allogene.com Cited by 354 |
Single-cell RNA-Seq of follicular lymphoma reveals malignant B-cell types and coexpression of T-cell immune checkpoints
Follicular lymphoma (FL) is a low-grade B-cell malignancy that transforms into a highly
aggressive and lethal disease at a rate of 2% per year. Perfect isolation of the malignant B-cell …
aggressive and lethal disease at a rate of 2% per year. Perfect isolation of the malignant B-cell …
Joint single cell DNA-seq and RNA-seq of gastric cancer cell lines reveals rules of in vitro evolution
Cancer cell lines are not homogeneous nor are they static in their genetic state and biological
properties. Genetic, transcriptional and phenotypic diversity within cell lines contributes to …
properties. Genetic, transcriptional and phenotypic diversity within cell lines contributes to …
Improved read/write cost tradeoff in DNA-based data storage using LDPC codes
With the amount of data being stored increasing rapidly, there is significant interest in exploring
alternative storage technologies. In this context, DNA-based storage systems can offer …
alternative storage technologies. In this context, DNA-based storage systems can offer …
Overcoming high nanopore basecaller error rates for DNA storage via basecaller-decoder integration and convolutional codes
As magnetization and semiconductor based storage technologies approach their limits, bio-molecules,
such as DNA, have been identified as promising media for future storage systems…
such as DNA, have been identified as promising media for future storage systems…
Improved detection and identification of microsatellite instability features in colorectal cancer: Implications for immunotherapy
G Shin, HJ Lee, SM Grimes, MA Kubit, HP Ji - Cancer Research, 2018 - AACR
Colorectal cancers with loss of DNA mismatch repair display microsatellite instability (MSI).
These tumors have a better prognosis and an improved response rate to immune check point …
These tumors have a better prognosis and an improved response rate to immune check point …
Characterization of the consensus mucosal microbiome of colorectal cancer
Dysbioisis is an imbalance of an organ's microbiome and plays a role in colorectal cancer
pathogenesis. Characterizing the bacteria in the microenvironment of a cancer through …
pathogenesis. Characterizing the bacteria in the microenvironment of a cancer through …
Joint single cell DNA-Seq and RNA-Seq of cancer reveals subclonal signatures of genomic instability and gene expression
Sequencing the genomes of individual cancer cells provides the highest resolution of
intratumoral heterogeneity. To enable high throughput single cell DNA-Seq across thousands of …
intratumoral heterogeneity. To enable high throughput single cell DNA-Seq across thousands of …
[HTML][HTML] Whole genome analysis identifies the association of TP53 genomic deletions with lower survival in Stage III colorectal cancer
DNA copy number aberrations (CNA) are frequently observed in colorectal cancers (CRC).
There is an urgent need for CNA-based biomarkers in clinics,. n For Stage III CRC, if …
There is an urgent need for CNA-based biomarkers in clinics,. n For Stage III CRC, if …
Tandem oligonucleotide probe annealing and elongation to discriminate viral sequence
New approaches for genomic DNA/RNA detection are in high demand in order to provide
controls for existing enzymatic technologies and to create alternatives for emerging …
controls for existing enzymatic technologies and to create alternatives for emerging …
The Gastric Cancer Registry: A Genomic Translational Resource for Multidisciplinary Research in Gastric Cancer
…, M McNamara, AC Hooker, MM Arce, M Kubit… - … Biomarkers & Prevention, 2022 - AACR
Background: Gastric cancer is a leading cause of cancer morbidity and mortality. Developing
information systems which integrate clinical and genomic data may accelerate discoveries …
information systems which integrate clinical and genomic data may accelerate discoveries …