Stimulator of interferon genes (STING) is an antiviral signalling protein that is broadly
conserved in both innate immunity in animals and phage defence in prokaryotes 1 , 2 , 3 – 4 . …

10.7554/eLife.40486.001 The cellular levels and activities of ribosomes directly regulate
gene expression during numerous physiological processes. The mechanisms that globally …

Bardet-Biedl syndrome (BBS) is a currently incurable ciliopathy caused by the failure to
correctly establish or maintain cilia-dependent signaling pathways. Eight proteins associated …

Ribosomes that stall inappropriately during protein synthesis harbor proteotoxic components
linked to cellular stress and neurodegenerative diseases. Molecular mechanisms that …

The Saccharomyces cerevisiae protein Ddi1 and its homologs in higher eukaryotes have
been proposed to serve as shuttling factors that deliver ubiquitinated substrates to the …

Aberrantly stalled ribosomes initiate the ribosome-associated quality control (RQC) and mRNA
surveillance pathways for the degradation of potentially toxic peptides and faulty mRNAs. …

Ribosome-associated quality control (RQC) disassembles aberrantly stalled translation
complexes to recycle or degrade the constituent parts. A key step of RQC is the cleavage of P-…

Translation termination is an essential cellular process, which is also of therapeutic interest
for diseases that manifest from premature stop codons. In eukaryotes, translation termination …

Close coordination between chaperones is essential for protein biosynthesis, including the
delivery of tail-anchored (TA) proteins containing a single C-terminal transmembrane domain …

The E2/E3 enzyme UBE2O ubiquitylates diverse clients to mediate important processes,
including targeting unassembled ‘orphan’ proteins for quality control and clearing ribosomes …