Embryonal rhabdomyosarcoma (ERMS) is a devastating cancer with specific features of muscle
differentiation that can result from mutational activation of RAS family members. However…

Pancreatitis is caused by inflammatory injury to the exocrine pancreas, from which both
humans and animal models appear to recover via regeneration of digestive enzyme–producing …

RAS family members are among the most frequently mutated oncogenes in human cancers.
Given the utility of zebrafish in both chemical and genetic screens, developing RAS-induced …

Defining the genetic pathways essential for hematopoietic stem cell (HSC) development
remains a fundamental goal impacting stem cell biology and regenerative medicine. To …

The size of the pancreas is determined by intrinsic factors, such as the number of progenitor
cells, and by extrinsic signals that control the fate and proliferation of those progenitors. Both …

X-linked adrenoleukodystrophy (ALD) is a devastating inherited neurodegenerative disease
caused by defects in the ABCD1 gene and affecting peripheral and central nervous system …

Vanishing white matter disease (VWM) is a severe leukodystrophy of the central nervous
system caused by mutations in subunits of the eukaryotic initiation factor 2B complex (eIF2B). …

Tools for genetically-determined visualization of synaptic circuits and interactions are
necessary to build connectomics of the vertebrate brain and to screen synaptic properties in …

Objective To identify novel disease associated loci for amyotrophic lateral sclerosis (ALS),
we used sequencing data and performed in vitro and in vivo experiments to demonstrate …

Purpose Methotrexate chemotherapy is associated with various toxicities which can result in
the interruption or discontinuation of treatment and a subsequently raised risk of relapse. …