The cellular functions of the actin cytoskeleton require precise regulation of both the
initiation of actin polymerization and the organization of the resulting filaments. The actin-related …

For over a decade, the actin-related protein 2/3 (ARP2/3) complex, a handful of nucleation-promoting
factors and formins were the only molecules known to directly nucleate actin …

The pathogenic bacterium Listeria monocytogenes is capable of directed movement within
the cytoplasm of infected host cells. Propulsion is thought to be driven by actin polymerization …

Actin filament assembly at the cell surface of the pathogenic bacterium Listeria monocytogenes
requires the bacterial ActA surface protein and the host cell Arp2/3 complex. Purified Arp2…

▪ Abstract Eukaryotic cells use actin polymerization to change shape, move, and internalize
extracellular materials by phagocytosis and endocytosis, and to form contractile structures. In …

The Arp2/3 protein complex has been implicated in the control of actin polymerization in
cells. The human complex consists of seven subunits which include the actin related proteins …

The actin cytoskeleton is harnessed by several pathogenic bacteria that are capable of
entering into non-phagocytic cells, the so-called ‘invasive bacteria’. Among them, a few also …

Mycobacteria are responsible for a number of human and animal diseases and are classical
intracellular pathogens, living inside macrophages rather than as free-living organisms …

The Arp2/3 complex is an actin nucleator that plays a critical role in many cellular processes.
Its activities are regulated by nucleation-promoting factors (NPFs) that function primarily …

We report the development and characterization of an in vitro system for the formation of
filopodia-like bundles. Beads coated with actin-related protein 2/3 (Arp2/3)–activating proteins …