Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …

Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology.
Understanding the genetic factors contributing to the shared and disorder-specific symptoms …

DNA sample contamination is a serious problem in DNA sequencing studies and may result
in systematic genotype misclassification and false positive associations. Although methods …

Bipolar disorder (BP) is a disabling and often life-threatening disorder that affects ≈1% of
the population worldwide. To identify genetic variants that increase the risk of BP, we …

LocusZoom.js is a JavaScript library for creating interactive web-based visualizations of
genetic association study results. It can display one or more traits in the context of relevant …

Genetic risk prediction has several potential applications in medical research and clinical
practice and could be used, for example, to stratify a heterogeneous population of patients by …

A detailed understanding of the genome-wide variability of single-nucleotide germline
mutation rates is essential to studying human genome evolution. Here, we use ~36 million …

Background Mood disorders (including major depressive disorder and bipolar disorder)
affect 10% to 20% of the population. They range from brief, mild episodes to severe, …

Importance Complex disorders, such as bipolar disorder (BD), likely result from the influence
of both common and rare susceptibility alleles. While common variation has been widely …

Associations between human genetic variation and clinical phenotypes have become a
foundation of biomedical research. Most repositories of these data seek to be disease-agnostic …