Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer
therapies, thereby limiting their effectiveness 1 , 2 , 3 , 4 . A high-mesenchymal cell state …

Abstract Changes in cellular gene expression in response to small-molecule or genetic
perturbations have yielded signatures that can connect unknown mechanisms of action (MoA) to …

Identifying genetic alterations that prime a cancer cell to respond to a particular therapeutic
agent can facilitate the development of precision cancer medicines. Cancer cell-line (CCL) …

Anticancer uses of non-oncology drugs have occasionally been found, but such discoveries
have been serendipitous. We sought to create a public resource containing the growth-…

To accelerate the translation of cancer nanomedicine, we used an integrated genomic
approach to improve our understanding of the cellular processes that govern nanoparticle …

Immune checkpoint blockade is effective for some patients with cancer, but most are refractory
to current immunotherapies and new approaches are needed to overcome resistance 1 , …

CDK4/6 kinase activation represents a common mechanism by which oncogenic signaling
induces proliferation and is potentially targetable by ATP competitive inhibitors. We identify a …

Glucose is vital for life, serving as both a source of energy and carbon building block for
growth. When glucose is limiting, alternative nutrients must be harnessed. To identify …

The paradigm of cancer-targeted therapies has focused largely on inhibition of critical pathways
in cancer. Conversely, conditional activation of signaling pathways as a new source of …

GCKR variants across the allelic spectrum have effects on glucose and lipid homeostasis.
Functional analysis has highlighted numerous molecular mechanisms for GKRP dysfunction. …