The genome is organized via CTCF–cohesin-binding sites, which partition chromosomes into
1–5 megabase (Mb) topologically associated domains (TADs), and further into smaller sub-…

Predicting the impact of noncoding genetic variation requires interpreting it in the context of
three-dimensional genome architecture. We have developed deepC, a transfer-learning-…

… Matthew D Gosden acted as honorary actuarial consultant to the project. We thank Peter
R Brinsden (formerly Bourn Hall Clinic, UK), Jie Deng (Yale University), Zeev Shoham (Kaplan …

Mammalian gene expression patterns are controlled by regulatory elements, which interact
within topologically associating domains (TADs). The relationship between activation of …

β-Thalassemia is one of the most common inherited anemias, with no effective cure for most
patients. The pathophysiology reflects an imbalance between α- and β-globin chains with …

The chromatin remodeller ATRX interacts with the histone chaperone DAXX to deposit the
histone variant H3.3 at sites of nucleosome turnover. ATRX is known to bind repetitive, …

Chromosome conformation capture (3C) provides an adaptable tool for studying diverse
biological questions. Current 3C methods generally provide either low-resolution interaction …

Several distinct differentiation protocols for deriving pancreatic progenitors (PPs) from human
pluripotent stem cells have been described, but it remains to be shown how similar the PPs …

The T-box transcription factor (TF) Eomes is a key regulator of cell fate decisions during
early mouse development. The cis-acting regulatory elements that direct expression in the …

Mammalian genomes are subdivided into large (50-2000 kb) regions of chromatin referred to
as Topologically Associating Domains (TADs or sub-TADs). Chromatin within an individual …