User profiles for Matthew Helm
 | Matthew HelmUSDA-ARS, Purdue University Verified email at purdue.edu Cited by 354 |
Mechanistic studies into amine-mediated electrophilic arene borylation and its application in MIDA boronate synthesis
…, JA Carrillo, IA Cade, MD Helm… - Journal of the …, 2013 - ACS Publications
Direct electrophilic borylation using Y 2 BCl (Y 2 = Cl 2 or o-catecholato) with equimolar AlCl
3 and a tertiary amine has been applied to a wide range of arenes and heteroarenes. In situ …
3 and a tertiary amine has been applied to a wide range of arenes and heteroarenes. In situ …
Discovery and characterization of highly potent and selective allosteric USP7 inhibitors
G Gavory, CR O'Dowd, MD Helm, J Flasz… - Nature chemical …, 2018 - nature.com
Given the importance of ubiquitin-specific protease 7 (USP7) in oncogenic pathways,
identification of USP7 inhibitors has attracted considerable interest. Despite substantial efforts, …
identification of USP7 inhibitors has attracted considerable interest. Despite substantial efforts, …
Using decoys to expand the recognition specificity of a plant disease resistance protein
Maintaining high crop yields in an environmentally sustainable manner requires the
development of disease-resistant crop varieties. We describe a method to engineer disease …
development of disease-resistant crop varieties. We describe a method to engineer disease …
Simple inexpensive boron electrophiles for direct arene borylation
A Del Grosso, MD Helm, SA Solomon… - Chemical …, 2011 - pubs.rsc.org
Simple inexpensive boron electrophiles for direct arene borylation - Chemical Communications
(RSC Publishing) DOI:10.1039/C1CC14226G Royal Society of Chemistry View PDF …
(RSC Publishing) DOI:10.1039/C1CC14226G Royal Society of Chemistry View PDF …
Total Synthesis of (+)‐Pleuromutilin
NJ Fazakerley, MD Helm… - Chemistry–A European …, 2013 - Wiley Online Library
The first enantiospecific total synthesis of the antibacterial natural product (+)‐pleuromutilin
has been achieved. The approach includes the synthesis of a non‐racemic cyclisation …
has been achieved. The approach includes the synthesis of a non‐racemic cyclisation …
A sydnone cycloaddition route to pyrazole boronic esters.
DL Browne, MD Helm, A Plant… - Asian Journal of …, 2013 - search.ebscohost.com
The article presents a research that examines a direct route approach for conducting the
synthesis of pyrazole boronic esters which would enable a broad range of analogues to be …
synthesis of pyrazole boronic esters which would enable a broad range of analogues to be …
Keratinocytes and immune cells in the epidermis are key drivers of inflammation in hidradenitis suppurativa providing a rationale for novel topical therapies
…, SR Goldberg, JS Kirby, MF Helm… - British Journal of …, 2023 - academic.oup.com
Background Hidradenitis suppurativa (HS) is a debilitating inflammatory skin disease
characterized by painful nodules, drainage and scarring in skin folds. Injectable adalimumab is the …
characterized by painful nodules, drainage and scarring in skin folds. Injectable adalimumab is the …
[HTML][HTML] RNA-Seq analysis implicates dysregulation of the immune system in schizophrenia
Background While genome-wide association studies identified some promising candidates
for schizophrenia, the majority of risk genes remained unknown. We were interested in …
for schizophrenia, the majority of risk genes remained unknown. We were interested in …
Identification and structure-guided development of pyrimidinone based USP7 inhibitors
CR O'Dowd, MD Helm, JSS Rountree… - ACS medicinal …, 2018 - ACS Publications
Ubiquitin specific protease 7 (USP7, HAUSP) has become an attractive target in drug
discovery due to the role it plays in modulating Mdm2 levels and consequently p53. Increasing …
discovery due to the role it plays in modulating Mdm2 levels and consequently p53. Increasing …
Engineering a decoy substrate in soybean to enable recognition of the soybean mosaic virus NIa protease
In Arabidopsis, recognition of the AvrPphB effector protease from Pseudomonas syringae is
mediated by the disease resistance (R) protein RPS5, which is activated by AvrPphB-…
mediated by the disease resistance (R) protein RPS5, which is activated by AvrPphB-…