Nucleosome-binding proteins act to modulate the promoter chromatin architecture and
transcription of target genes. We used genomic and gene-specific approaches to show that two …

In mammals, nic o tin a mide phosphoribosyltransferase (NAMPT) and nic o tin a mide
mononucleotide ad en y lyltransferase 1 (NMNAT-1) constitute a nuclear NAD + salvage pathway …

Oncogene-induced senescence (OIS) is a tumor-suppressive mechanism typified by stable
proliferative arrest, a persistent DNA damage response, and the senescence-associated …

MacroH2A1 is a histone variant that is enriched on the inactive X chromosome (Xi) in
mammals and is postulated to play an important, but unknown, role in the repression of gene …

The histone variant macroH2A1 contains a carboxyl-terminal ∼30-kDa domain called a macro
domain. MacroH2A1 is produced as one of two alternatively spliced forms, macroH2A1.1 …

Poly(ADP-ribose) polymerase-1 (PARP-1) and poly(ADP-ribose) glycohydrolase (PARG)
are enzymes that modify target proteins by the addition and removal, respectively, of ADP-…

Peptidylarginine deiminase IV (PADI4) catalyzes the conversion of positively charged
arginine and methylarginine residues to neutrally charged citrulline, and this activity has been …

NMNAT-1 and PARP-1, two key enzymes in the NAD + metabolic pathway, localize to the
nucleus where integration of their enzymatic activities has the potential to control a variety of …

The histone variant macroH2A1 regulates gene expression important for differentiation, stem-cell
reprogramming and tumor suppression. Here, we demonstrate that in primary human …

The histone chaperone SET is required for transcription of chromatin templates by RNA
polymerase Pol II (Pol II) in vitro. Here we uncover a positive role for SET in dislodging DEK and …