User profiles for Matthew J. McBride
Matthew J. McBrideAssistant professor at Rutgers University Verified email at rutgers.edu Cited by 1673 |
[PDF][PDF] Cancer-specific retargeting of BAF complexes by a prion-like domain
…, ME Awad, S Rengarajan, A Volorio, MJ McBride… - Cell, 2017 - cell.com
Alterations in transcriptional regulators can orchestrate oncogenic gene expression
programs in cancer. Here, we show that the BRG1/BRM-associated factor (BAF) chromatin …
programs in cancer. Here, we show that the BRG1/BRM-associated factor (BAF) chromatin …
A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation
…, N Mashtalir, ZM McKenzie, MJ McBride… - Nature cell …, 2018 - nature.com
Mammalian SWI/SNF chromatin remodelling complexes exist in three distinct, final-form
assemblies: canonical BAF (cBAF), PBAF and a newly characterized non-canonical complex (…
assemblies: canonical BAF (cBAF), PBAF and a newly characterized non-canonical complex (…
SMARCB1 is required for widespread BAF complex–mediated activation of enhancers and bivalent promoters
Perturbations to mammalian SWI/SNF (mSWI/SNF or BAF) complexes contribute to more
than 20% of human cancers, with driving roles first identified in malignant rhabdoid tumor, an …
than 20% of human cancers, with driving roles first identified in malignant rhabdoid tumor, an …
[PDF][PDF] The SS18-SSX fusion oncoprotein hijacks BAF complex targeting and function to drive synovial sarcoma
MJ McBride, JL Pulice, HC Beird, DR Ingram… - Cancer cell, 2018 - cell.com
Synovial sarcoma (SS) is defined by the hallmark SS18-SSX fusion oncoprotein, which
renders BAF complexes aberrant in two manners: gain of SSX to the SS18 subunit and …
renders BAF complexes aberrant in two manners: gain of SSX to the SS18 subunit and …
A novel SS18-SSX fusion-specific antibody for the diagnosis of synovial sarcoma
E Baranov, MJ McBride, AM Bellizzi… - The American journal …, 2020 - journals.lww.com
Synovial sarcoma (SS), an aggressive soft tissue sarcoma with a predilection for the extremities
of young adults, harbors the pathognomonic t (X; 18)(p11; q11) translocation, resulting in …
of young adults, harbors the pathognomonic t (X; 18)(p11; q11) translocation, resulting in …
Convergent and complementary selection shaped gains and losses of eusociality in sweat bees
…, K Goodwin, SM Davidson, MJ McBride… - Nature Ecology & …, 2023 - nature.com
Sweat bees have repeatedly gained and lost eusociality, a transition from individual to group
reproduction. Here we generate chromosome-length genome assemblies for 17 species …
reproduction. Here we generate chromosome-length genome assemblies for 17 species …
Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma
…, HR Weisman, ND Mathewson, MJ McBride… - Nature medicine, 2021 - nature.com
Synovial sarcoma (SyS) is an aggressive neoplasm driven by the SS18–SSX fusion, and is
characterized by low T cell infiltration. Here, we studied the cancer–immune interplay in SyS …
characterized by low T cell infiltration. Here, we studied the cancer–immune interplay in SyS …
[PDF][PDF] Binding of TMPRSS2-ERG to BAF chromatin remodeling complexes mediates prostate oncogenesis
Chromosomal rearrangements resulting in the fusion of TMPRSS2, an androgen-regulated
gene, and the ETS family transcription factor ERG occur in over half of prostate cancers. …
gene, and the ETS family transcription factor ERG occur in over half of prostate cancers. …
[PDF][PDF] Local production of lactate, ribose phosphate, and amino acids by human triple-negative breast cancer
…, SJ Facista, C Mueller, AJ Cowan, MJ McBride… - Med, 2021 - cell.com
Background Upregulated glucose metabolism is a common feature of tumors. Glucose can
be broken down by either glycolysis or the oxidative pentose phosphate pathway (oxPPP). …
be broken down by either glycolysis or the oxidative pentose phosphate pathway (oxPPP). …
Effects of antibiotic-producing Streptomyces on nodulation and leaf spot in alfalfa
The ability of antibiotic-producing streptomycetes to colonize alfalfa (Medicago sativa L.)
plants and influence the activities of a fungal plant pathogen (Phoma medicaginis var. …
plants and influence the activities of a fungal plant pathogen (Phoma medicaginis var. …