Breast cancers in BRCA1 mutation carriers frequently have a distinctive basal-like phenotype.
It has been suggested that this results from an origin in basal breast epithelial stem cells. …

Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B (PKB/AKT),
and mammalian target of rapamycin (mTOR) pathway is a frequent event in prostate …

Introduction Breast cancer remains a significant scientific, clinical and societal challenge.
This gap analysis has reviewed and critically assessed enduring issues and new challenges …

… Primary mouse mammary epithelial cells were harvested essentially as described by
Smalley et al. [8], with … AJ Alvi, H Clayton and MJ Smalley contributed equally to this work. …

Introduction Breast cancer is thought to arise in mammary epithelial stem cells. There is,
therefore, a large amount of interest in identifying these cells. The breast is a complex tissue …

… Isacke, Alan Ashworth, Matthew J. Smalley; Dissociation of estrogen receptor expression
and in vivo stem cell activity in the mammary gland . J Cell Biol 1 January 2007; 176 (1): 19–26. …

The identification of mammary epithelial stem cells raises the hypothesis that these cells
may be crucial in the pathogenesis of breast cancer. To further support this, a highly …

Dishevelled (DVL) is associated with axonal microtubules and regulates microtubule
stability through the inhibition of the serine/threonine kinase, glycogen synthase kinase 3β (GSK-3β…

Wnt signalling is involved in a variety of mammalian developmental processes, including cell
proliferation, differentiation and epithelial–mesenchymal interactions, through which they …

Axin promotes the phosphorylation of β‐catenin by GSK‐3β, leading to β‐catenin degradation.
Wnt signals interfere with β‐catenin turnover, resulting in enhanced transcription of target …