[HTML][HTML] Shared and distinct transcriptomic cell types across neocortical areas
The neocortex contains a multitude of cell types that are segregated into layers and functionally
distinct areas. To investigate the diversity of cell types across the mouse neocortex, here …
distinct areas. To investigate the diversity of cell types across the mouse neocortex, here …
[HTML][HTML] Comparative cellular analysis of motor cortex in human, marmoset and mouse
The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals 1 . Here, using high-throughput transcriptomic and epigenomic …
conserved across mammals 1 . Here, using high-throughput transcriptomic and epigenomic …
[PDF][PDF] A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation
…, LT Graybuck, MJ Hawrylycz, D Hirschstein, M Kroll… - Cell, 2021 - cell.com
The isocortex and hippocampal formation (HPF) in the mammalian brain play critical roles
in perception, cognition, emotion, and learning. We profiled ∼1.3 million cells covering the …
in perception, cognition, emotion, and learning. We profiled ∼1.3 million cells covering the …
[PDF][PDF] Integrated morphoelectric and transcriptomic classification of cortical GABAergic cells
…, DJ Hill, M Hupp, S Kebede, TK Kim, L Kim, M Kroll… - Cell, 2020 - cell.com
Neurons are frequently classified into distinct types on the basis of structural, physiological,
or genetic attributes. To better constrain the definition of neuronal cell types, we …
or genetic attributes. To better constrain the definition of neuronal cell types, we …
[HTML][HTML] Human neocortical expansion involves glutamatergic neuron diversification
The neocortex is disproportionately expanded in human compared with mouse 1 , 2 , both
in its total volume relative to subcortical structures and in the proportion occupied by …
in its total volume relative to subcortical structures and in the proportion occupied by …
[HTML][HTML] Single-nucleus and single-cell transcriptomes compared in matched cortical cell types
…, N Dee, E Garren, J Goldy, LT Graybuck, M Kroll… - PloS one, 2018 - journals.plos.org
Transcriptomic profiling of complex tissues by single-nucleus RNA-sequencing (snRNA-seq)
affords some advantages over single-cell RNA-sequencing (scRNA-seq). snRNA-seq …
affords some advantages over single-cell RNA-sequencing (scRNA-seq). snRNA-seq …
Local connectivity and synaptic dynamics in mouse and human neocortex
…, M Clark, N Dee, L Ellingwood, J Gloe, M Kroll… - Science, 2022 - science.org
We present a unique, extensive, and open synaptic physiology analysis platform and dataset.
Through its application, we reveal principles that relate cell type to synaptic properties and …
Through its application, we reveal principles that relate cell type to synaptic properties and …
Classification of electrophysiological and morphological neuron types in the mouse visual cortex
…, DJ Hill, S Josephsen, S Kebede, L Kim, M Kroll… - Nature …, 2019 - nature.com
Understanding the diversity of cell types in the brain has been an enduring challenge and
requires detailed characterization of individual neurons in multiple dimensions. To …
requires detailed characterization of individual neurons in multiple dimensions. To …
[HTML][HTML] A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
The mammalian brain consists of millions to billions of cells that are organized into many cell
types with specific spatial distribution patterns and structural and functional properties 1 , 2 …
types with specific spatial distribution patterns and structural and functional properties 1 , 2 …
[HTML][HTML] A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex
Single-cell transcriptomics can provide quantitative molecular signatures for large, unbiased
samples of the diverse cell types in the brain 1 , 2 – 3 . With the proliferation of multi-omics …
samples of the diverse cell types in the brain 1 , 2 – 3 . With the proliferation of multi-omics …