The non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, has an important
role in signal transduction downstream of growth factor receptor signalling and was the …

Background Immobilisation predicts adverse outcomes in patients in the surgical intensive
care unit (SICU). Attempts to mobilise critically ill patients early after surgery are frequently …

Somatic mutations in DNMT3A, which encodes a de novo DNA methyltransferase, are found
in ∼30% of normal karyotype acute myeloid leukemia (AML) cases. Most mutations are …

Defects in epigenetic regulation play a fundamental role in the development of cancer, and
epigenetic regulators have recently emerged as promising therapeutic candidates. We …

In his 1665 treatise, Micrographia, Robert Hooke described the many observations he had
made using a microscope, including compartment-like structures in cork samples that he …

The mechanism of the ene reaction of singlet ( 1 Δ g ) oxygen with simple alkenes is
investigated by a combination of experimental isotope effects and several levels of theoretical …

Background While spending to prepare precollege students for engineering at universities
increases, the number of engineering graduates continues to decrease, and attrition rates for …

SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene
involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also …

Background The development of blood-based biomarker tests that are accurate and robust
for Alzheimer’s disease (AD) pathology have the potential to aid clinical diagnosis and …

BACKGROUND For many years, basic and clinical researchers have taken advantage of the
analytical sensitivity and specificity afforded by mass spectrometry in the measurement of …