[HTML][HTML] Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging …

…, PW Barrett, A Beane, A Burrell, MP Cheng… - ERJ open …, 2022 - Eur Respiratory Soc
Due to the large number of patients with severe coronavirus disease 2019 (COVID-19), many
were treated outside the traditional walls of the intensive care unit (ICU), and in many cases…

A cell-free DNA metagenomic sequencing assay that integrates the host injury response to infection

AP Cheng, P Burnham, JR Lee… - Proceedings of the …, 2019 - National Acad Sciences
High-throughput metagenomic sequencing offers an unbiased approach to identify pathogens
in clinical samples. Conventional metagenomic sequencing, however, does not integrate …

Adapting serosurveys for the SARS-CoV-2 vaccine era

…, C Cao, C Gurry, CA Hankins, MP Cheng… - Open forum …, 2022 - academic.oup.com
Population-level immune surveillance, which includes monitoring exposure and assessing
vaccine-induced immunity, is a crucial component of public health decision-making during a …

[PDF][PDF] Cell-free DNA tissues of origin by methylation profiling reveals significant cell, tissue, and organ-specific injury related to COVID-19 severity

AP Cheng, MP Cheng, W Gu, JS Lenz, E Hsu, E Schurr… - Med, 2021 - cell.com
Background Coronavirus disease 2019 (COVID-19) primarily affects the lungs, but evidence
of systemic disease with multi-organ involvement is emerging. Here, we developed a blood …

A systems biology approach identifies candidate drugs to reduce mortality in severely ill patients with COVID-19

…, M Orlova, P Cassart, DC Vinh, MP Cheng… - Science …, 2022 - science.org
Despite the availability of highly efficacious vaccines, coronavirus disease 2019 (COVID-19)
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lacks effective …

Cell-free DNA profiling informs all major complications of hematopoietic cell transplantation

AP Cheng, MP Cheng, CJ Loy… - Proceedings of the …, 2022 - National Acad Sciences
Allogeneic hematopoietic cell transplantation (HCT) provides effective treatment for
hematologic malignancies and immune disorders. Monitoring of posttransplant complications is …

[HTML][HTML] Angiotensin receptor blockers and angiotensin-converting enzyme inhibitors in COVID-19: meta-analysis/meta-regression adjusted for confounding factors

T Lee, A Cau, MP Cheng, A Levin, TC Lee, DC Vinh… - CJC open, 2021 - Elsevier
Background Angiotensin receptor blockers (ARBs) and/or angiotensin-converting enzyme (ACE)
inhibitors could alter mortality from coronavirus disease 2019 (COVID-19), but existing …

Validation of extracorporeal membrane oxygenation mortality prediction and severity of illness scores in an international COVID‐19 cohort

…, M Chand, A Chen, YS Chen, MP Cheng… - Artificial …, 2023 - Wiley Online Library
Background Veno‐venous extracorporeal membrane oxygenation (V‐V ECMO) is a lifesaving
support modality for severe respiratory failure, but its resource‐intensive nature led to …

[HTML][HTML] Cell-free DNA in blood reveals significant cell, tissue and organ specific injury and predicts COVID-19 severity

AP Cheng, MP Cheng, W Gu, JS Lenz, E Hsu, E Schurr… - medRxiv, 2020 - ncbi.nlm.nih.gov
COVID-19 primarily affects the lungs, but evidence of systemic disease with multi-organ
involvement is emerging. Here, we developed a blood test to broadly quantify cell, tissue, and …

Voice-based screening for SARS-CoV-2 exposure in cardiovascular clinics

…, E Oulousian, J Ni, R Lopes, MP Cheng… - … Heart Journal-Digital …, 2021 - academic.oup.com
Aims Artificial intelligence (AI) driven voice-based assistants may facilitate data capture in
clinical care and trials; however, the feasibility and accuracy of using such devices in a …