The CD19 antigen, expressed on most B-cell acute lymphoblastic leukemias (B-ALL), can
be targeted with chimeric antigen receptor–armed T cells (CART-19), but relapses with …

10.7554/eLife.11752.001 Alternative splicing (AS) can critically affect gene function and
disease, yet mapping splicing variations remains a challenge. Here, we propose a new …

Every successful cancer therapy story has Exhibit B, comprised of patients who either did not
respond to the initial treatment or acquired resistance after a seemingly curative intervention…

Three of the eight RNA segments encoded by the influenza A virus (IAV) undergo alternative
splicing to generate distinct proteins. Previously, we found that host proteins hnRNP K and …

Alternative splicing is prevalent among genes encoding signaling molecules; however, the
functional consequence of differential isoform expression remains largely unknown. Here we …

Motivation Advancements in sequencing technologies have highlighted the role of alternative
splicing (AS) in increasing transcriptome complexity. This role of AS, combined with the …

Despite the success and fast adaptation of deep learning models in biomedical domains,
their lack of interpretability remains an issue. Here, we introduce Enhanced Integrated …

Studies in several cell types have highlighted dramatic and diverse changes in mRNA
processing that occur upon cellular stimulation. However, the mechanisms and pathways that …

Aberrant splicing is a hallmark of leukemias with mutations in splicing factor (SF)-encoding
genes. Here we investigated its prevalence in pediatric B-cell acute lymphoblastic leukemias (…

The tremendous rate with which data is generated and analysis methods emerge makes it
increasingly difficult to keep track of their domain of applicability, assumptions, limitations, and …