The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape
Enzymes that catalyse CpG methylation in DNA, including the DNA methyltransferases 1 (DNMT1),
3A (DNMT3A) and 3B (DNMT3B), are indispensable for mammalian tissue …
3A (DNMT3A) and 3B (DNMT3B), are indispensable for mammalian tissue …
Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands
Precise deposition of CpG methylation is critical for mammalian development and tissue
homeostasis and is often dysregulated in human diseases. The localization of de novo DNA …
homeostasis and is often dysregulated in human diseases. The localization of de novo DNA …
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization
…, M Zhou, N Mehta, MR Marunde… - Nature chemical …, 2022 - nature.com
Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible
for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active …
for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active …
[HTML][HTML] Quantification of citrullinated histones: Development of an improved assay to reliably quantify nucleosomal H3Cit in human plasma
C Thålin, K Aguilera, NW Hall, MR Marunde… - Journal of Thrombosis …, 2020 - Elsevier
Background Recent data propose a diagnostic and prognostic capacity for citrullinated
histone H3 (H3Cit), a marker of neutrophil extracellular traps (NETs), in pathologic conditions …
histone H3 (H3Cit), a marker of neutrophil extracellular traps (NETs), in pathologic conditions …
[HTML][HTML] Characterization of the plant homeodomain (PHD) reader family for their histone tail interactions
K Jain, CS Fraser, MR Marunde, MM Parker… - Epigenetics & …, 2020 - Springer
Background Plant homeodomain (PHD) fingers are central “readers” of histone post-translational
modifications (PTMs) with > 100 PHD finger-containing proteins encoded by the …
modifications (PTMs) with > 100 PHD finger-containing proteins encoded by the …
Nucleosome conformation dictates the histone code
MR Marunde, HA Fuchs, JM Burg, IK Popova, A Vaidya… - Elife, 2024 - elifesciences.org
Histone post-translational modifications (PTMs) play a critical role in chromatin regulation. It
has been proposed that these PTMs form localized ‘codes’ that are read by specialized …
has been proposed that these PTMs form localized ‘codes’ that are read by specialized …
An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability
In nucleosomes, histone N-terminal tails exist in dynamic equilibrium between free/accessible
and collapsed/DNA-bound states. The latter state is expected to impact histone N-termini …
and collapsed/DNA-bound states. The latter state is expected to impact histone N-termini …
Structure and flexibility of the yeast NuA4 histone acetyltransferase complex
SA Zukin, MR Marunde, IK Popova, KM Soczek… - Elife, 2022 - elifesciences.org
The NuA4 protein complex acetylates histones H4 and H2A to activate both transcription and
DNA repair. We report the 3.1-Å resolution cryo-electron microscopy structure of the central …
DNA repair. We report the 3.1-Å resolution cryo-electron microscopy structure of the central …
[PDF][PDF] Independent transcriptomic and proteomic regulation by type I and II protein arginine methyltransferases
Protein arginine methyltransferases (PRMTs) catalyze the post-translational monomethylation
(Rme1), asymmetric (Rme2a), or symmetric (Rme2s) dimethylation of arginine. To …
(Rme1), asymmetric (Rme2a), or symmetric (Rme2s) dimethylation of arginine. To …
Improved tolerance to salt and water stress in Drosophila melanogaster cells conferred by late embryogenesis abundant protein
MR Marunde, DA Samarajeewa, J Anderson… - Journal of insect …, 2013 - Elsevier
Mechanisms that govern anhydrobiosis involve the accumulation of highly hydrophilic
macromolecules, such as late embryogenesis abundant (LEA) proteins. Group 1 LEA proteins …
macromolecules, such as late embryogenesis abundant (LEA) proteins. Group 1 LEA proteins …