Several aggregation-prone proteins associated with neurodegenerative diseases can be
modified by O-linked N-acetyl-glucosamine (O-GlcNAc) in vivo. One of these proteins, α-…

Despite advances in genetic and proteomic techniques, a complete portrait of the proteome
and its complement of dynamic interactions and modifications remains a lofty, and as of yet, …

The dynamic modification of nuclear and cytoplasmic proteins by the monosaccharide N-acetyl-glucosamine
(GlcNAc) continues to emerge as an important regulator of many biological …

Investigations into the roles of protein glycosylation have revealed functions such as modulating
protein structure and localization, cell–cell recognition, and signaling in multicellular …

The ubiquitin E3 ligase substrate adapter cereblon (CRBN) is a target of thalidomide and
lenalidomide 1 , therapeutic agents used in the treatment of haematopoietic malignancies 2 , 3 …

A compelling link is emerging between the posttranslational modification O-GlcNAc and
protein aggregation. A prime example is α-synuclein, which forms toxic aggregates that are …

▪ Abstract Protein glycosylation is widely recognized as a modulator of protein structure,
localization, and cell-cell recognition in multicellular systems. Glycoproteins are typically …

Metabolic chemical reporters (MCRs) of glycosylation are analogues of monosaccharides
that contain bioorthogonal functionalities and enable the direct visualization and identification …

The process of neurodegeneration in Parkinson’s Disease is intimately associated with the
aggregation of the protein α-synuclein into toxic oligomers and fibrils. Interestingly, many of …

A major role for the intracellular post-translational modification O-GlcNAc appears to be the
inhibition of protein aggregation. Most of the previous studies in this area focused on O-…