[HTML][HTML] Alpha-glucosidase inhibitors alter gut microbiota and ameliorate collagen-induced arthritis

…, P Song, X Zhang, C Metea, M Schleisman… - Frontiers in …, 2020 - frontiersin.org
Acarose is an anti-diabetic drug and exhibits anti-arthritic effects. We hypothesized that
acarbose influences the gut microbiota to affect the course of arthritis and tested this hypothesis …

Preliminary report on interleukin-22, GM-CSF, and IL-17F in the pathogenesis of acute anterior uveitis

JCC Huang, M Schleisman, D Choi… - Ocular immunology …, 2021 - Taylor & Francis
Purpose:Anterior uveitis is the most common anatomic subset of uveitis. We developed a novel
multi-parametric flow cytometry panel to identify immune dysregulation signatures in HLA …

[HTML][HTML] Axial spondyloarthritis patients have altered mucosal IgA response to oral and fecal microbiota

…, T Laderas, TM Martin, S Davin, M Schleisman… - Frontiers in …, 2022 - frontiersin.org
Axial spondyloarthritis (axSpA) is an inflammatory arthritis involving the spine and the sacroiliac
joint with extra-articular manifestations in the eye, gut, and skin. The intestinal microbiota …

Expression of Cytokines in Porcine Iris, Retina and Choroidal Tissues Stimulated by Microbe-associated Molecular Patterns

…, JT Rosenbaum, M Schleisman… - Current Eye …, 2021 - Taylor & Francis
Purpose The innate immune system is strongly implicated in the pathogenesis of uveitis. This
study was designed to clarify the responses of the innate immune system in uveal tissues. …

[HTML][HTML] Multicolor flow cytometry analysis of peripheral blood mononuclear cells from patients with sarcoidosis associated uveitis reveals novel cytokine and …

JCC Huang, M Schleisman… - … & Visual Science, 2020 - iovs.arvojournals.org
Purpose: The precise pathogenesis of sarcoidosis and associated uveitis is still under
investigation. The potential contribution of mucosal-associated lymphoid subsets including …

Deep Profiling of Circulating Immune Cells in Uveitis Patients with Spondylitis Indicates an Increase of CCR9+ Gut Homing Cells

J Siak, M Schleisman, C Mitchell… - … & Visual Science, 2019 - iovs.arvojournals.org
Purpose: To identify immune cell phenotypes which predict the association with systemic
spondylitis among patients with acute anterior uveitis using mass cytometry (CyTOF) deep …

Conventional and Non-conventional Lymphocytes exhibit dysregulated IL-22 and GM-CSF production in Acute Anterior Uveitis and Ankylosing Spondylitis

JCC Huang, M Schleisman, C Mitchell… - … & Visual Science, 2019 - iovs.arvojournals.org
Purpose: Underlying immune mechanisms that drive the HLA-B* 27-associated inflammatory
diseases acute anterior uveitis (AAU) and Ankylosing Spondylitis (AS) are incompletely …

Expression of cytokines in porcine iris, retina and choroid tissues stimulated by microbe-associated molecular patterns

…, JT Rosenbaum, M Schleisman… - … & Visual Science, 2018 - iovs.arvojournals.org
Purpose: The gut microbiota has been associated with immune-mediated uveitis in several
studies. Mounting evidence indicates that translocation of microbes or microbial products …

Distinct functions of pancreatic stellate cells in PDAC stromal evolution

MKC Onate, M Schleisman, Z Xia, MH Sherman - Cancer Research, 2022 - AACR
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers in the United
States with a five-year relative survival rate of 10.8%. After surgery, radiation and …

Monitoring glycolytic dynamics in single cells using a fluorescent biosensor for fructose 1, 6-bisphosphate

JN Koberstein, ML Stewart, CB Smith… - Proceedings of the …, 2022 - National Acad Sciences
Matthew Schleisman for assistance with FACS; Yibing Jia for help with DNA sequencing;
Stephanie Kaech for her expertise in microscopy; Erkan Karakas and Carsten Shultz for helpful …