A substantial and increasing number of human diseases are associated with changes in the
gut microbiota, and discovering the molecules and mechanisms underlying these …

Active inflammatory bowel disease (IBD) often coincides with increases of Ruminococcus
gnavus, a gut microbe found in nearly everyone. It was not known how, or if, this correlation …

Bariatric surgery, the most effective treatment for obesity and type 2 diabetes, is associated
with increased levels of the incretin hormone glucagon-like peptide-1 (GLP-1) and changes …

The microbial world offers a rich source of bioactive compounds for those able to sift through
it. Technologies capable of quantitatively detecting natural products while simultaneously …

Multiple epidemiological studies identify Dolosigranulum pigrum as a candidate beneficial
bacterium based on its positive association with health, including negative associations with …

Covering: up to 2016 In this highlight, we describe the current landscape for dereplication
and discovery of natural products based on the measurement of the intact mass by LC-MS. …

Despite containing an α-amino acid, the versatile cofactor S-adenosylmethionine (SAM) is not
a known building block for nonribosomal peptide synthetase (NRPS) assembly lines. Here …

SHP2 is a protein tyrosine phosphatase that plays a critical role in the full activation of the
Ras-MAPK pathway upon stimulation of receptor tyrosine kinases, which are frequently …

Unlocking the biochemical stores of fungi is key for developing future pharmaceuticals.
Through reduced expression of a critical histone deacetylase in Aspergillus nidulans, increases …

New classes of antibiotics are desperately needed in our fight against antibiotic-resistant
bacterial infections. Jia et al. publish a new "multi-armed" antibiotic scaffold that effectively …