Diffuse gliomas, particularly glioblastomas, are incurable brain tumours 1 . They are
characterized by networks of interconnected brain tumour cells that communicate via Ca 2+ …

Metastatic seeding is driven by cell-intrinsic and environmental cues, yet the contribution of
biomechanics is poorly known. We aim to elucidate the impact of blood flow on the arrest and …

Intravital microscopy provides dynamic understanding of multiple cell biological processes,
but its limited resolution has so far precluded structural analysis. Because it is difficult to …

Studying key biological events within complex model systems relies on dynamic and
functional imaging at optimum spatial and temporal resolutions. Intravital correlative light and …

Background Brain metastases (BM) are a frequent complication of malignant melanoma (MM),
with limited treatment options and poor survival. Prevention of BM could be more effective …

Tracking single extravasating cancer cells using multimodal correlative microscopy
uncovers a brain seeding mechanism involving endothelial remodeling driven by cancer cell–…

Clinically relevant brain metastases (BMs) frequently form in cancer patients, with limited
options for effective treatment. Circulating cancer cells must first permanently arrest in brain …

Cancer cells responsible for successful brain metastasis outgrowth are slow cycling and
harbor stemness features. The molecular characteristics of these metastasis-initiating cells can …

Rationale: Glioblastoma is the most frequent, primary brain tumor that is characterized by a
highly immunosuppressive tumor microenvironment (TME). The TME plays a key role for …

Combining in vivo imaging with electron microscopy (EM) uniquely allows monitoring rare
and critical events in living tissue, followed by their high-resolution visualization in their native …